Sandbox Reserved 708: Difference between revisions
| Line 13: | Line 13: | ||
Considering the roles plaid by GSK3 in promoting both pathological features of Alzheimer disease, GSK3-inhibitors may act positively in the therapy of Alzheimer’s patients. But due to the importance of its role in numerous cellular functions, it is important to develop inhibitors that do not affect or suppress its primary activity,<ref>5 Hu S (Feb 2009). "GSK3 inhibitors show benefits in an Alzheimer's disease (AD) model of neurodegeneration but adverse effects in control animals.". Neurobiol Dis. 33 (2): 193-206. doi:10.1016/j.nbd.2008.10.007. PMID 19038340.</ref>. | Considering the roles plaid by GSK3 in promoting both pathological features of Alzheimer disease, GSK3-inhibitors may act positively in the therapy of Alzheimer’s patients. But due to the importance of its role in numerous cellular functions, it is important to develop inhibitors that do not affect or suppress its primary activity,<ref>5 Hu S (Feb 2009). "GSK3 inhibitors show benefits in an Alzheimer's disease (AD) model of neurodegeneration but adverse effects in control animals.". Neurobiol Dis. 33 (2): 193-206. doi:10.1016/j.nbd.2008.10.007. PMID 19038340.</ref>. | ||
There are two isoforms of GSK-3: GSK3α | There are two isoforms of GSK-3: GSK3α and GSK3β,<ref>Neurochem Res. 2007; 32(4-5): 577-595. Glycogen Synthase Kinase-3 (GSK3): Inflammation, Diseases, and Therapeutics, Richard S. Jope,* Christopher J. Yuskaitis, and Eléonore Beurel</ref>. | ||
. Our concern focuses on GSK3 two mechanisms that affect the activity of the kinase are its inhibition by phosphorylation of serine-9 and its activity enhancement by phosphorylation of tyrosine-216,<ref>Journal of biological Chemistry 2005: GSK-3β Directly Phosphorylates and Activates MARK2/PAR-1, Shinichi Kosuga1, Etsu Tashiro1, Toshifumi Kajioka, Mayumi Ueki, Yoshifumi Shimizu and Masaya Imoto2</ref>. | . Our concern focuses on GSK3 two mechanisms that affect the activity of the kinase are its inhibition by phosphorylation of serine-9 and its activity enhancement by phosphorylation of tyrosine-216,<ref>Journal of biological Chemistry 2005: GSK-3β Directly Phosphorylates and Activates MARK2/PAR-1, Shinichi Kosuga1, Etsu Tashiro1, Toshifumi Kajioka, Mayumi Ueki, Yoshifumi Shimizu and Masaya Imoto2</ref>. | ||