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New page: left|200px<br /><applet load="1tf3" size="450" color="white" frame="true" align="right" spinBox="true" caption="1tf3" /> '''TFIIIA FINGER 1-3 BOUND TO DNA, NMR, 22 STRU... |
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[[Image:1tf3.gif|left|200px]]<br /><applet load="1tf3" size=" | [[Image:1tf3.gif|left|200px]]<br /><applet load="1tf3" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1tf3" /> | caption="1tf3" /> | ||
'''TFIIIA FINGER 1-3 BOUND TO DNA, NMR, 22 STRUCTURES'''<br /> | '''TFIIIA FINGER 1-3 BOUND TO DNA, NMR, 22 STRUCTURES'''<br /> | ||
==Overview== | ==Overview== | ||
The three N-terminal zinc fingers of transcription factor IIIA bind in the | The three N-terminal zinc fingers of transcription factor IIIA bind in the DNA major groove. Substantial packing interfaces are formed between adjacent fingers, the linkers lose their intrinsic flexibility upon DNA binding, and several lysine side chains implicated in DNA recognition are dynamically disordered. | ||
==About this Structure== | ==About this Structure== | ||
1TF3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 1TF3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TF3 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Xenopus laevis]] | [[Category: Xenopus laevis]] | ||
[[Category: Case, D | [[Category: Case, D A.]] | ||
[[Category: Foster, M | [[Category: Foster, M P.]] | ||
[[Category: Gottesfeld, J | [[Category: Gottesfeld, J M.]] | ||
[[Category: Radhakrishnan, I.]] | [[Category: Radhakrishnan, I.]] | ||
[[Category: Wright, P | [[Category: Wright, P E.]] | ||
[[Category: Wuttke, D | [[Category: Wuttke, D S.]] | ||
[[Category: ZN]] | [[Category: ZN]] | ||
[[Category: 5s rna gene]] | [[Category: 5s rna gene]] | ||
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[[Category: zinc finger]] | [[Category: zinc finger]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:12:50 2008'' | ||
Revision as of 16:12, 21 February 2008
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TFIIIA FINGER 1-3 BOUND TO DNA, NMR, 22 STRUCTURES
OverviewOverview
The three N-terminal zinc fingers of transcription factor IIIA bind in the DNA major groove. Substantial packing interfaces are formed between adjacent fingers, the linkers lose their intrinsic flexibility upon DNA binding, and several lysine side chains implicated in DNA recognition are dynamically disordered.
About this StructureAbout this Structure
1TF3 is a Single protein structure of sequence from Xenopus laevis with as ligand. Full crystallographic information is available from OCA.
ReferenceReference
Domain packing and dynamics in the DNA complex of the N-terminal zinc fingers of TFIIIA., Foster MP, Wuttke DS, Radhakrishnan I, Case DA, Gottesfeld JM, Wright PE, Nat Struct Biol. 1997 Aug;4(8):605-8. PMID:9253405
Page seeded by OCA on Thu Feb 21 15:12:50 2008