1py5: Difference between revisions

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{{Seed}}
[[Image:1py5.png|left|200px]]
[[Image:1py5.png|left|200px]]


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{{STRUCTURE_1py5|  PDB=1py5  |  SCENE=  }}  
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===Crystal Structure of TGF-beta receptor I kinase with inhibitor===
===Crystal Structure of TGF-beta receptor I kinase with inhibitor===


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{{ABSTRACT_PUBMED_15177479}}
{{ABSTRACT_PUBMED_15177479}}
==Disease==
Known disease associated with this structure: Loeys-Dietz syndrome, type 1A OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=190181 190181]], Loeys-Dietz syndrome, type 2A OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=190181 190181]]


==About this Structure==
==About this Structure==
1PY5 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PY5 OCA].  
[[1py5]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PY5 OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:15177479</ref><references group="xtra"/>
<ref group="xtra">PMID:015177479</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Receptor i]]
[[Category: Receptor i]]
[[Category: Tgf-beta]]
[[Category: Tgf-beta]]
 
[[Category: Transferase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 05:31:12 2009''

Revision as of 12:50, 2 January 2013

File:1py5.png

Template:STRUCTURE 1py5

Crystal Structure of TGF-beta receptor I kinase with inhibitorCrystal Structure of TGF-beta receptor I kinase with inhibitor

Template:ABSTRACT PUBMED 15177479

About this StructureAbout this Structure

1py5 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

[xtra 1]

  1. ↑ Sawyer JS, Beight DW, Britt KS, Anderson BD, Campbell RM, Goodson T Jr, Herron DK, Li HY, McMillen WT, Mort N, Parsons S, Smith EC, Wagner JR, Yan L, Zhang F, Yingling JM. Synthesis and activity of new aryl- and heteroaryl-substituted 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain. Bioorg Med Chem Lett. 2004 Jul 5;14(13):3581-4. PMID:15177479 doi:http://dx.doi.org/10.1016/j.bmcl.2004.04.007

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