1t6v: Difference between revisions
New page: left|200px<br /> <applet load="1t6v" size="450" color="white" frame="true" align="right" spinBox="true" caption="1t6v, resolution 1.70Å" /> '''Crystal structure a... |
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[[Image:1t6v.gif|left|200px]]<br /> | [[Image:1t6v.gif|left|200px]]<br /><applet load="1t6v" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1t6v" size=" | |||
caption="1t6v, resolution 1.70Å" /> | caption="1t6v, resolution 1.70Å" /> | ||
'''Crystal structure analysis of the nurse shark new antigen receptor (NAR) variable domain in complex with lysozyme'''<br /> | '''Crystal structure analysis of the nurse shark new antigen receptor (NAR) variable domain in complex with lysozyme'''<br /> | ||
==Overview== | ==Overview== | ||
Cartilaginous fish are the phylogenetically oldest living organisms known | Cartilaginous fish are the phylogenetically oldest living organisms known to possess components of the vertebrate adaptive immune system. Key to their immune response are heavy-chain, homodimeric immunoglobulins called new antigen receptors (IgNARs), in which the variable (V) domains recognize antigens with only a single immunoglobulin domain, akin to camelid heavy-chain V domains. The 1.45 angstrom resolution crystal structure of the type I IgNAR V domain in complex with hen egg-white lysozyme (HEL) reveals a minimal antigen-binding domain that contains only two of the three conventional complementarity-determining regions but still binds HEL with nanomolar affinity by means of a binding interface comparable in size to conventional antibodies. | ||
==About this Structure== | ==About this Structure== | ||
1T6V is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Ginglymostoma_cirratum Ginglymostoma cirratum] with CL as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] Full crystallographic information is available from [http:// | 1T6V is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus] and [http://en.wikipedia.org/wiki/Ginglymostoma_cirratum Ginglymostoma cirratum] with <scene name='pdbligand=CL:'>CL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T6V OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Dooley, H.]] | [[Category: Dooley, H.]] | ||
[[Category: Flajnik, M | [[Category: Flajnik, M F.]] | ||
[[Category: Stanfield, R | [[Category: Stanfield, R L.]] | ||
[[Category: Wilson, I | [[Category: Wilson, I A.]] | ||
[[Category: CL]] | [[Category: CL]] | ||
[[Category: immunoglobulin fold]] | [[Category: immunoglobulin fold]] | ||
[[Category: protein-protein complex]] | [[Category: protein-protein complex]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:10:29 2008'' | ||
