1eaq: Difference between revisions
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Revision as of 16:05, 30 October 2007
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THE RUNX1 RUNT DOMAIN AT 1.25A RESOLUTION: A STRUCTURAL SWITCH AND SPECIFICALLY BOUND CHLORIDE IONS MODULATE DNA BINDING
OverviewOverview
The evolutionarily conserved Runt homology domain is characteristic of the, RUNX family of heterodimeric eukaryotic transcription factors, including, RUNX1, RUNX2 and RUNX3. The genes for RUNX1, also termed acute myeloid, leukemia protein 1, AML1, and its dimerization partner core-binding factor, beta, CBFbeta, are essential for hematopoietic development and are, together the most common targets for gene rearrangements in acute human, leukemias. Here, we describe the crystal structure of the uncomplexed, RUNX1 Runt domain at 1.25A resolution and compare its conformation to, previously published structures in complex with DNA, CBFbeta or both. We, find that complex formation induces significant structural rearrangements, in this immunoglobulin (Ig)-like DNA-binding domain. Most pronounced ... [(full description)]
About this StructureAbout this Structure
1EAQ is a [Single protein] structure of sequence from [Mus musculus] with CL as [ligand]. Structure known Active Site: CL1. Full crystallographic information is available from [OCA].
ReferenceReference
The RUNX1 Runt domain at 1.25A resolution: a structural switch and specifically bound chloride ions modulate DNA binding., Backstrom S, Wolf-Watz M, Grundstrom C, Hard T, Grundstrom T, Sauer UH, J Mol Biol. 2002 Sep 13;322(2):259-72. PMID:12217689
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