1swm: Difference between revisions
New page: left|200px<br /><applet load="1swm" size="450" color="white" frame="true" align="right" spinBox="true" caption="1swm, resolution 1.8Å" /> '''X-RAY CRYSTAL STRUCTU... |
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[[Image:1swm.gif|left|200px]]<br /><applet load="1swm" size=" | [[Image:1swm.gif|left|200px]]<br /><applet load="1swm" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1swm, resolution 1.8Å" /> | caption="1swm, resolution 1.8Å" /> | ||
'''X-RAY CRYSTAL STRUCTURE OF THE FERRIC SPERM WHALE MYOGLOBIN: IMIDAZOLE COMPLEX AT 2.0 ANGSTROMS RESOLUTION'''<br /> | '''X-RAY CRYSTAL STRUCTURE OF THE FERRIC SPERM WHALE MYOGLOBIN: IMIDAZOLE COMPLEX AT 2.0 ANGSTROMS RESOLUTION'''<br /> | ||
==Overview== | ==Overview== | ||
The X-ray crystal structure of the ferric sperm whale (Physeter catodon) | The X-ray crystal structure of the ferric sperm whale (Physeter catodon) myoglobin:imidazole complex has been refined at 2.0 A resolution, to a final R-factor of 14.8%. The overall conformation of the protein is little affected by binding of the ligand. Imidazole is co-ordinated to the heme iron at the distal site, and forces distinguishable local changes in the surrounding protein residues. His64(E7) swings out of the distal pocket and becomes substantially exposed to the solvent: nevertheless, it stabilizes the exogenous ligand by hydrogen bonding. The side-chains of residues Arg45(CD3) and Asp60(E3) are also affected by imidazole association. | ||
==About this Structure== | ==About this Structure== | ||
1SWM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Physeter_catodon Physeter catodon] with AZI, SO4 and HEM as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | 1SWM is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Physeter_catodon Physeter catodon] with <scene name='pdbligand=AZI:'>AZI</scene>, <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=HEM:'>HEM</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SWM OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: oxygen transport]] | [[Category: oxygen transport]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:06:05 2008'' | ||
Revision as of 16:06, 21 February 2008
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X-RAY CRYSTAL STRUCTURE OF THE FERRIC SPERM WHALE MYOGLOBIN: IMIDAZOLE COMPLEX AT 2.0 ANGSTROMS RESOLUTION
OverviewOverview
The X-ray crystal structure of the ferric sperm whale (Physeter catodon) myoglobin:imidazole complex has been refined at 2.0 A resolution, to a final R-factor of 14.8%. The overall conformation of the protein is little affected by binding of the ligand. Imidazole is co-ordinated to the heme iron at the distal site, and forces distinguishable local changes in the surrounding protein residues. His64(E7) swings out of the distal pocket and becomes substantially exposed to the solvent: nevertheless, it stabilizes the exogenous ligand by hydrogen bonding. The side-chains of residues Arg45(CD3) and Asp60(E3) are also affected by imidazole association.
About this StructureAbout this Structure
1SWM is a Single protein structure of sequence from Physeter catodon with , and as ligands. Full crystallographic information is available from OCA.
ReferenceReference
X-ray crystal structure of the ferric sperm whale myoglobin: imidazole complex at 2.0 A resolution., Lionetti C, Guanziroli MG, Frigerio F, Ascenzi P, Bolognesi M, J Mol Biol. 1991 Feb 5;217(3):409-12. PMID:1994031
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