User:Jing Huang/Sandbox 1: Difference between revisions
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= Anthrax Protective Antigen = | = Anthrax Protective Antigen = | ||
[http://en.wikipedia.org/wiki/Anthrax_toxin Anthrax toxin] complex consists of three nontoxic proteins: protective antigen (PA), lethal factor (LF), and endema factor (EF). PA forms pore and delivers LF and EF, which lead to lethal shock and edema of the host separately, to the cytosol. Formation of the toxin complex starts when PA binds to the cellular receptors and is cleaved into two fragments. The smaller fragment PA-20 (20 kDa) dissociates and the remaining receptor-bound fragment PA-63 (63 kDa) self-assemblies to a ring-shaped heptameric oligomer, a pore precursor (<scene name='User:Jing_Huang/Sandbox_1/Prepore/1'>prepore</scene>). LF and/or EF binds to the PA63 prepore to form a toxic complex. Oligomerization of PA-63 causes the endocytosis and the complex is trafficked to an acidic compartment. The PA-63 heptamer converts from the prepore to the pore state and translocates LF/EF into the cell. | [http://en.wikipedia.org/wiki/Anthrax_toxin Anthrax toxin] complex consists of three nontoxic proteins: protective antigen (<scene name='User:Jing_Huang/Sandbox_1/Pa-63/1'>PA</scene>), lethal factor ([http://en.wikipedia.org/wiki/Anthrax_lethal_factor_endopeptidase LF]), and endema factor (EF). PA forms pore and delivers LF and EF, which lead to lethal shock and edema of the host separately, to the cytosol. Formation of the toxin complex starts when PA binds to the cellular receptors and is cleaved into two fragments. The smaller fragment PA-20 (20 kDa) dissociates and the remaining receptor-bound fragment PA-63 (63 kDa) self-assemblies to a ring-shaped heptameric oligomer, a pore precursor (<scene name='User:Jing_Huang/Sandbox_1/Prepore/1'>prepore</scene>). LF and/or EF binds to the PA63 prepore to form a toxic complex. Oligomerization of PA-63 causes the endocytosis and the complex is trafficked to an acidic compartment. The PA-63 heptamer converts from the prepore to the pore state and translocates LF/EF into the cell. | ||
<Structure load='1ACC' size='500' frame='true' align='right' caption='Anthrax Protective Atigen (PDB ID: [http://www.rcsb.org/pdb/explore/explore.do?structureId=1acc 1ACC]PA)' scene='Insert optional scene name here' /> | <Structure load='1ACC' size='500' frame='true' align='right' caption='Anthrax Protective Atigen (PDB ID: [http://www.rcsb.org/pdb/explore/explore.do?structureId=1acc 1ACC]PA)' scene='Insert optional scene name here' /> | ||
<scene name='User:Jing_Huang/Sandbox_1/Prepore/1'>prepore</scene> | <scene name='User:Jing_Huang/Sandbox_1/Prepore/1'>prepore</scene> | ||
Revision as of 18:07, 13 December 2012
Anthrax Protective AntigenAnthrax Protective Antigen
Anthrax toxin complex consists of three nontoxic proteins: protective antigen (), lethal factor (LF), and endema factor (EF). PA forms pore and delivers LF and EF, which lead to lethal shock and edema of the host separately, to the cytosol. Formation of the toxin complex starts when PA binds to the cellular receptors and is cleaved into two fragments. The smaller fragment PA-20 (20 kDa) dissociates and the remaining receptor-bound fragment PA-63 (63 kDa) self-assemblies to a ring-shaped heptameric oligomer, a pore precursor (). LF and/or EF binds to the PA63 prepore to form a toxic complex. Oligomerization of PA-63 causes the endocytosis and the complex is trafficked to an acidic compartment. The PA-63 heptamer converts from the prepore to the pore state and translocates LF/EF into the cell.
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