Caspase-3 Regulatory Mechanisms: Difference between revisions

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 ==== Natural Inhibitors====
-X-linked inhibitor of apoptosis proteins (XIAP) contains the second baculovirus IAP repeat domain (BIR2) targeting caspase-3 and caspase-7. <scene name='Caspase-3_Regulatory_Mechanisms/Bir2/1'>BIR2</scene>
+<scene name='Caspase-3_Regulatory_Mechanisms/Bir2/1'>Casp3 bound to BIR2 domain</scene>
+X-linked inhibitor of apoptosis proteins (XIAP) contains the second baculovirus IAP repeat domain (BIR2) targeting caspase-3 and caspase-7. The <scene name='Caspase-3_Regulatory_Mechanisms/Bir2/2'>BIR2</scene> domain sits directly in the active site of caspase-3 and completely inhibits the protein. The region binding the active site runs in the opposite direction of normal caspase-3 substrates, thus occupying P1 through P4 but avoiding cleavage by the protease. This unique method of inhibition is a critical regulatory mechanism used in cells to control apoptotic caspase activity.
 =Reference=