User:Elizabeth R. Haglin/Sandbox 1: Difference between revisions

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== Structure ==

[[Image:CheA_domains.png|410px|left|thumb|CheA Domains <ref>PMID: 22494339</ref>]]

'''CheA''' exists as a homodimer of 71-kDa subunits. Each monomer catalyzes an ATP-dependent ''trans''-phosphorylation of a histidine. A monomer contains five domains (P1-P5 from N- to C-terminus) connected by highly dynamic linkers of various lengths. Each domain has a distinct function.Due to the size of CheA, the solved structures available to date do not have all five domains. Included in this proteopedia page are ~~[[2lp4]] which contains a~~ <scene name='User:Elizabeth_R._Haglin/Sandbox_1/P1_p2_chey/1'>P1P2</~~scene~~>-CheY complex, and [[1b3q]] with a dimer of P3P4P5.

'''CheA''' exists as a homodimer of 71-kDa subunits. Each monomer catalyzes an ATP-dependent ''trans''-phosphorylation of a histidine. A monomer contains five domains (P1-P5 from N- to C-terminus) connected by highly dynamic linkers of various lengths. Each domain has a distinct function.Due to the size of CheA, the solved structures available to date do not have all five domains. Included in this proteopedia page are <scene name='User:Elizabeth_R._Haglin/Sandbox_1/P1_p2_chey/1'>[[2lp4]]</scene> which contains a P1P2-CheY complex, and [[1b3q]] with a dimer of P3P4P5.

*P1: histidine phosphotransfer domain (HPt) mediates phosphate transfer from ATP to CheY

*P2: CheY binding domain releases CheY-P upon small conformational changes

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 == Structure ==
 [[Image:CheA_domains.png|410px|left|thumb|CheA Domains <ref>PMID: 22494339</ref>]]
-'''CheA''' exists as a homodimer of 71-kDa subunits. Each monomer catalyzes an ATP-dependent ''trans''-phosphorylation of a histidine.  A monomer contains five domains (P1-P5 from N- to C-terminus) connected by highly dynamic linkers of various lengths.  Each domain has a distinct function.Due to the size of CheA, the solved structures available to date do not have all five domains.  Included in this proteopedia page are [[2lp4]] which contains a <scene name='User:Elizabeth_R._Haglin/Sandbox_1/P1_p2_chey/1'>P1P2</scene>-<font color= 'red'>CheY</font> complex, and [[1b3q]] with a dimer of P3P4P5.
+'''CheA''' exists as a homodimer of 71-kDa subunits. Each monomer catalyzes an ATP-dependent ''trans''-phosphorylation of a histidine.  A monomer contains five domains (P1-P5 from N- to C-terminus) connected by highly dynamic linkers of various lengths.  Each domain has a distinct function.Due to the size of CheA, the solved structures available to date do not have all five domains.  Included in this proteopedia page are <scene name='User:Elizabeth_R._Haglin/Sandbox_1/P1_p2_chey/1'>[[2lp4]]</scene> which contains a <font color='gainsboro'>P1P2</font>-<font color='red'>CheY</font> complex, and [[1b3q]] with a dimer of P3P4P5.
 *P1: histidine phosphotransfer domain (HPt) mediates phosphate transfer from ATP to CheY
 *P2: CheY binding domain releases CheY-P upon small conformational changes