Molecular Playground/Transferrin: Difference between revisions

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Revision as of 12:18, 31 January 2012 view source Michal Harel (talk \| contribs) 31,761 edits No edit summary ← Older edit		Revision as of 21:33, 11 December 2012 view source Jake Pawlowski (talk \| contribs) 11 edits No edit summary Newer edit →
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	Transferrin delivers iron to iron requiring cells by receptor-mediated endocytosis. At basic pH of cell surface diferric human transferrin binds to human transferrin receptor (hTfR). Upon binding, diferric hTf-hTfR is internalized in the cell by endocytosis. In the acidic condition of endosome iron is release from diferric hTf-hTfR complex into the cells. The ApohTf-hTfR complex is recycled back to the cell surface and at the basic pH of cell surface Tf dissociates from the TfR to bind iron again.<ref>PMID: 16271884</ref><ref>PMID: 6300904</ref>.		Transferrin delivers iron to iron requiring cells by receptor-mediated endocytosis. At basic pH of cell surface diferric human transferrin binds to human transferrin receptor (hTfR). Upon binding, diferric hTf-hTfR is internalized in the cell by endocytosis. In the acidic condition of endosome iron is release from diferric hTf-hTfR complex into the cells. The ApohTf-hTfR complex is recycled back to the cell surface and at the basic pH of cell surface Tf dissociates from the TfR to bind iron again.<ref>PMID: 16271884</ref><ref>PMID: 6300904</ref>.


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