6-deoxyerythronolide B synthase (DEBS): Difference between revisions
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<applet load='3EL6' size='[450,338]' frame='true' align='right' | <applet load='3EL6' size='[450,338]' frame='true' align='right' | ||
caption='Crystal Structure of the Erythromycin Dehydratase complex with sulfate and Cl- ion ([[3el6]])' scene='User:Tsung-Yi Lin/6-deoxyerythronolide B synthase/> | caption='Crystal Structure of the dimeric Erythromycin Dehydratase monomer complex with sulfate and Cl- ion ([[3el6]])' scene='User:Tsung-Yi Lin/6-deoxyerythronolide B synthase/> | ||
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Molecular Playground banner: cyclize the molecule, "the closer". | Molecular Playground banner: cyclize the molecule, "the closer". | ||
<applet load='1MO2' size='[450,338]' frame='true' align='right' | <applet load='1MO2' size='[450,338]' frame='true' align='right' | ||
caption='Thioesterase Domain from 6-Deoxyerythronolide Synthase (DEBS TE)([[1mo2]])' scene='User:Tsung-Yi Lin/6-deoxyerythronolide B synthase/> | caption='Thioesterase Domain from 6-Deoxyerythronolide Synthase dimer (DEBS TE)([[1mo2]])' scene='User:Tsung-Yi Lin/6-deoxyerythronolide B synthase/> | ||
TE is the terminal domain in DEBS, releasing the completed polyketide from the synthase by forming a 14-membered lactone. It is able to close such a large ring by threading it into a large inner cavity which stabilizes its conformation while esterification occurs. | TE is the terminal domain in DEBS, releasing the completed polyketide from the synthase by forming a 14-membered lactone. It is able to close such a large ring by threading it into a large inner cavity which stabilizes its conformation while esterification occurs. | ||