SandboxPKA: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 14: | Line 14: | ||
The fusion of the gene encoding c-Abl with the breakpoint cluster region (BCR) gene, results in the formation of a fusion protein, BCR-Abl, in which all of c-Abl is preserved without mutation, except for the “cap” region upstream of the SH3 domain. | The fusion of the gene encoding c-Abl with the breakpoint cluster region (BCR) gene, results in the formation of a fusion protein, BCR-Abl, in which all of c-Abl is preserved without mutation, except for the “cap” region upstream of the SH3 domain. | ||
<StructureSection load='1OPK' size='250' side='right' caption= | <StructureSection load='1OPK' size='250' side='right' caption='c-Abl tyrosine kinase: SH3 doamain is shown in red while SH2 domain is shown in purple. Catalytic domain is represented by blue. Also it is possible to observe myristoiled group in the N-terminal domain of c-Abl tyrosin kinase' scene='SandboxPKA/Abl1/4'> | ||
==='''Kinase domain'''=== | ==='''Kinase domain'''=== | ||