1s1s: Difference between revisions
New page: left|200px<br /><applet load="1s1s" size="450" color="white" frame="true" align="right" spinBox="true" caption="1s1s, resolution 2.10Å" /> '''Crystal Structure of... |
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[[Image:1s1s.gif|left|200px]]<br /><applet load="1s1s" size=" | [[Image:1s1s.gif|left|200px]]<br /><applet load="1s1s" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1s1s, resolution 2.10Å" /> | caption="1s1s, resolution 2.10Å" /> | ||
'''Crystal Structure of ZipA in complex with indoloquinolizin 10b'''<br /> | '''Crystal Structure of ZipA in complex with indoloquinolizin 10b'''<br /> | ||
==Overview== | ==Overview== | ||
The binding of FtsZ to ZipA is a potential target for antibacterial | The binding of FtsZ to ZipA is a potential target for antibacterial therapy. Based on a small molecule inhibitor of the ZipA-FtsZ interaction, a parallel synthesis of small molecules was initiated which targeted a key region of ZipA involved in FtsZ binding. The X-ray crystal structure of one of these molecules complexed with ZipA was solved. The structure revealed an unexpected binding mode, facilitated by desolvation of a loosely bound surface water. | ||
==About this Structure== | ==About this Structure== | ||
1S1S is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with WAC as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 1S1S is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=WAC:'>WAC</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S1S OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Ding, W.]] | [[Category: Ding, W.]] | ||
[[Category: Dushin, E | [[Category: Dushin, E G.]] | ||
[[Category: Foreman, K | [[Category: Foreman, K W.]] | ||
[[Category: III, T | [[Category: III, T S.Rush.]] | ||
[[Category: Jennings, L | [[Category: Jennings, L D.]] | ||
[[Category: Kenny, C | [[Category: Kenny, C H.]] | ||
[[Category: Li, Y.]] | [[Category: Li, Y.]] | ||
[[Category: Moghazeh, S | [[Category: Moghazeh, S L.]] | ||
[[Category: Mosyak, L.]] | [[Category: Mosyak, L.]] | ||
[[Category: Petersen, P | [[Category: Petersen, P J.]] | ||
[[Category: Ruzin, A | [[Category: Ruzin, A V.]] | ||
[[Category: Sukhdeo, M | [[Category: Sukhdeo, M N.]] | ||
[[Category: Sutherland, A | [[Category: Sutherland, A G.]] | ||
[[Category: Tsao, D | [[Category: Tsao, D H.]] | ||
[[Category: Tuckman, M.]] | [[Category: Tuckman, M.]] | ||
[[Category: WAC]] | [[Category: WAC]] | ||
[[Category: cell cycle]] | [[Category: cell cycle]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:56:59 2008'' | ||
Revision as of 15:57, 21 February 2008
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Crystal Structure of ZipA in complex with indoloquinolizin 10b
OverviewOverview
The binding of FtsZ to ZipA is a potential target for antibacterial therapy. Based on a small molecule inhibitor of the ZipA-FtsZ interaction, a parallel synthesis of small molecules was initiated which targeted a key region of ZipA involved in FtsZ binding. The X-ray crystal structure of one of these molecules complexed with ZipA was solved. The structure revealed an unexpected binding mode, facilitated by desolvation of a loosely bound surface water.
About this StructureAbout this Structure
1S1S is a Single protein structure of sequence from Escherichia coli with as ligand. Full crystallographic information is available from OCA.
ReferenceReference
Design and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA-FtsZ interaction., Jennings LD, Foreman KW, Rush TS 3rd, Tsao DH, Mosyak L, Li Y, Sukhdeo MN, Ding W, Dushin EG, Kenny CH, Moghazeh SL, Petersen PJ, Ruzin AV, Tuckman M, Sutherland AG, Bioorg Med Chem Lett. 2004 Mar 22;14(6):1427-31. PMID:15006376
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