1s1j: Difference between revisions
New page: left|200px<br /><applet load="1s1j" size="450" color="white" frame="true" align="right" spinBox="true" caption="1s1j, resolution 2.18Å" /> '''Crystal Structure of... |
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[[Image:1s1j.jpg|left|200px]]<br /><applet load="1s1j" size=" | [[Image:1s1j.jpg|left|200px]]<br /><applet load="1s1j" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1s1j, resolution 2.18Å" /> | caption="1s1j, resolution 2.18Å" /> | ||
'''Crystal Structure of ZipA in complex with indoloquinolizin inhibitor 1'''<br /> | '''Crystal Structure of ZipA in complex with indoloquinolizin inhibitor 1'''<br /> | ||
==Overview== | ==Overview== | ||
The binding of FtsZ to ZipA is a potential target for antibacterial | The binding of FtsZ to ZipA is a potential target for antibacterial therapy. Based on a small molecule inhibitor of the ZipA-FtsZ interaction, a parallel synthesis of small molecules was initiated which targeted a key region of ZipA involved in FtsZ binding. The X-ray crystal structure of one of these molecules complexed with ZipA was solved. The structure revealed an unexpected binding mode, facilitated by desolvation of a loosely bound surface water. | ||
==About this Structure== | ==About this Structure== | ||
1S1J is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with IQZ as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 1S1J is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with <scene name='pdbligand=IQZ:'>IQZ</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1S1J OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Ding, W.]] | [[Category: Ding, W.]] | ||
[[Category: Dushin, E | [[Category: Dushin, E G.]] | ||
[[Category: Foreman, K | [[Category: Foreman, K W.]] | ||
[[Category: III, T | [[Category: III, T S.Rush.]] | ||
[[Category: Jenning, L | [[Category: Jenning, L D.]] | ||
[[Category: Kenney, C | [[Category: Kenney, C H.]] | ||
[[Category: Li, Y.]] | [[Category: Li, Y.]] | ||
[[Category: Moghazeh, S | [[Category: Moghazeh, S L.]] | ||
[[Category: Mosyak, L.]] | [[Category: Mosyak, L.]] | ||
[[Category: Peterson, P | [[Category: Peterson, P J.]] | ||
[[Category: Ruzin, A | [[Category: Ruzin, A V.]] | ||
[[Category: Sukhdeo, M | [[Category: Sukhdeo, M N.]] | ||
[[Category: Sutherland, A | [[Category: Sutherland, A G.]] | ||
[[Category: Tsao, D | [[Category: Tsao, D H.]] | ||
[[Category: Tuckman, M.]] | [[Category: Tuckman, M.]] | ||
[[Category: IQZ]] | [[Category: IQZ]] | ||
[[Category: cell cycle]] | [[Category: cell cycle]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:56:53 2008'' | ||
