1rwx: Difference between revisions
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==Overview== | ==Overview== | ||
Disulfide Tethering was applied to the active site of human caspase-1, resulting in the discovery of a novel, tricyclic molecular fragment that | Disulfide Tethering was applied to the active site of human caspase-1, resulting in the discovery of a novel, tricyclic molecular fragment that selectively binds in S4. This fragment was developed into a class of potent inhibitors of human caspase-1. Several key analogues determined the optimal distance of the tricycle from the catalytic residues, the relative importance of various features of the tricycle, and the importance of the linker. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Brien, T | [[Category: Brien, T O.]] | ||
[[Category: Fahr, B | [[Category: Fahr, B T.]] | ||
[[Category: Romanowski, M | [[Category: Romanowski, M J.]] | ||
[[Category: YBH]] | [[Category: YBH]] | ||
[[Category: hydrolase]] | [[Category: hydrolase]] | ||
[[Category: protein-small molecule inhibitor complex]] | [[Category: protein-small molecule inhibitor complex]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:55:24 2008'' | ||