1e1k: Difference between revisions
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ADRENODOXIN REDUCTASE IN COMPLEX WITH NADP+ OBTAINED BY A SOAKING EXPERIMENT
OverviewOverview
Adrenodoxin reductase is a flavoenzyme that shuffles electrons for the, biosynthesis of steroids. Its chain topology belongs to the glutathione, reductase family of disulfide oxidoreductases, all of which bind FAD at, equivalent positions. The three reported structures of adrenodoxin, reductase were ligated with reduced and oxidized NADP and have now, confirmed this equivalence also for the NADP-binding site. Remarkably, the, conformations and relative positions of the prosthetic group FAD and the, cofactor NADP have been conserved during protein evolution despite very, substantial changes in the polypeptide. The ligated enzymes showed small, changes in the domain positions. When compared with the structure of the, NADP-free enzyme, these positions correspond to several states of the, ... [(full description)]
About this StructureAbout this Structure
1E1K is a [Single protein] structure of sequence from [Bos taurus] with FAD and NAP as [ligands]. Structure known Active Sites: AC1 and AC2. Full crystallographic information is available from [OCA].
ReferenceReference
Crystal structures of adrenodoxin reductase in complex with NADP+ and NADPH suggesting a mechanism for the electron transfer of an enzyme family., Ziegler GA, Schulz GE, Biochemistry. 2000 Sep 12;39(36):10986-95. PMID:10998235
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