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New page: left|200px<br /><applet load="1rnd" size="450" color="white" frame="true" align="right" spinBox="true" caption="1rnd, resolution 1.5Å" /> '''NEWLY OBSERVED BINDIN... |
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[[Image:1rnd.gif|left|200px]]<br /><applet load="1rnd" size=" | [[Image:1rnd.gif|left|200px]]<br /><applet load="1rnd" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1rnd, resolution 1.5Å" /> | caption="1rnd, resolution 1.5Å" /> | ||
'''NEWLY OBSERVED BINDING MODE IN PANCREATIC RIBONUCLEASE'''<br /> | '''NEWLY OBSERVED BINDING MODE IN PANCREATIC RIBONUCLEASE'''<br /> | ||
==Overview== | ==Overview== | ||
Dinucleotides containing guanine, when soaked into crystals of bovine | Dinucleotides containing guanine, when soaked into crystals of bovine pancreatic ribonuclease, have been found to bind in an unexpected manner, quite unlike interpretations of earlier X-ray diffraction studies. This finding has prompted a reexamination of three mononucleotide-RNase complexes from this laboratory resulting in a re-interpretation of the complex that involved a guanine mononucleotide. | ||
==About this Structure== | ==About this Structure== | ||
1RND is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with SO4 and DGP as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] Full crystallographic information is available from [http:// | 1RND is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=DGP:'>DGP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RND OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Pancreatic ribonuclease]] | [[Category: Pancreatic ribonuclease]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Aguilar, C | [[Category: Aguilar, C F.]] | ||
[[Category: Mills, A.]] | [[Category: Mills, A.]] | ||
[[Category: Moss, D | [[Category: Moss, D S.]] | ||
[[Category: Palmer, R | [[Category: Palmer, R A.]] | ||
[[Category: Thomas, P | [[Category: Thomas, P J.]] | ||
[[Category: DGP]] | [[Category: DGP]] | ||
[[Category: SO4]] | [[Category: SO4]] | ||
[[Category: hydrolase(endoribonuclease)]] | [[Category: hydrolase(endoribonuclease)]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:52:38 2008'' | ||
Revision as of 15:52, 21 February 2008
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NEWLY OBSERVED BINDING MODE IN PANCREATIC RIBONUCLEASE
OverviewOverview
Dinucleotides containing guanine, when soaked into crystals of bovine pancreatic ribonuclease, have been found to bind in an unexpected manner, quite unlike interpretations of earlier X-ray diffraction studies. This finding has prompted a reexamination of three mononucleotide-RNase complexes from this laboratory resulting in a re-interpretation of the complex that involved a guanine mononucleotide.
About this StructureAbout this Structure
1RND is a Single protein structure of sequence from Bos taurus with and as ligands. Active as Pancreatic ribonuclease, with EC number 3.1.27.5 Full crystallographic information is available from OCA.
ReferenceReference
Newly observed binding mode in pancreatic ribonuclease., Aguilar CF, Thomas PJ, Mills A, Moss DS, Palmer RA, J Mol Biol. 1992 Mar 5;224(1):265-7. PMID:1548704
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