1rmd: Difference between revisions
New page: left|200px<br /> <applet load="1rmd" size="450" color="white" frame="true" align="right" spinBox="true" caption="1rmd, resolution 2.10Å" /> '''RAG1 DIMERIZATION D... |
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[[Image:1rmd.gif|left|200px]]<br /> | [[Image:1rmd.gif|left|200px]]<br /><applet load="1rmd" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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caption="1rmd, resolution 2.10Å" /> | caption="1rmd, resolution 2.10Å" /> | ||
'''RAG1 DIMERIZATION DOMAIN'''<br /> | '''RAG1 DIMERIZATION DOMAIN'''<br /> | ||
==Overview== | ==Overview== | ||
The crystal structure of the dimerization domain of the V(D)J | The crystal structure of the dimerization domain of the V(D)J recombination-activating protein, RAG1, was solved using zinc anomalous scattering. The structure reveals an unusual combination of multi-class zinc-binding motifs, including a zinc RING finger and a C2H2 zinc finger, that together from a single structural domain. The domain also contains a unique zinc binuclear cluster in place of a normally mononuclear zinc site in the RING finger. Together, four zinc ions help organize the entire domain, including the two helices that form the dimer interface. | ||
==About this Structure== | ==About this Structure== | ||
1RMD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 1RMD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RMD OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Bellon, S | [[Category: Bellon, S F.]] | ||
[[Category: Coleman, J | [[Category: Coleman, J E.]] | ||
[[Category: Rodgers, K | [[Category: Rodgers, K K.]] | ||
[[Category: Schatz, D | [[Category: Schatz, D G.]] | ||
[[Category: Steitz, T | [[Category: Steitz, T A.]] | ||
[[Category: ZN]] | [[Category: ZN]] | ||
[[Category: antibody]] | [[Category: antibody]] | ||
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[[Category: zinc finger]] | [[Category: zinc finger]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:52:25 2008'' | ||
Revision as of 15:52, 21 February 2008
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RAG1 DIMERIZATION DOMAIN
OverviewOverview
The crystal structure of the dimerization domain of the V(D)J recombination-activating protein, RAG1, was solved using zinc anomalous scattering. The structure reveals an unusual combination of multi-class zinc-binding motifs, including a zinc RING finger and a C2H2 zinc finger, that together from a single structural domain. The domain also contains a unique zinc binuclear cluster in place of a normally mononuclear zinc site in the RING finger. Together, four zinc ions help organize the entire domain, including the two helices that form the dimer interface.
About this StructureAbout this Structure
1RMD is a Single protein structure of sequence from Mus musculus with as ligand. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of the RAG1 dimerization domain reveals multiple zinc-binding motifs including a novel zinc binuclear cluster., Bellon SF, Rodgers KK, Schatz DG, Coleman JE, Steitz TA, Nat Struct Biol. 1997 Jul;4(7):586-91. PMID:9228952
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