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==Overview== | ==Overview== | ||
The three-dimensional structure of human carbonic anhydrase II complexed | The three-dimensional structure of human carbonic anhydrase II complexed with azide and with bromide was investigated crystallographically. Both of these non-protonated inhibitors replace the zinc and the 'deep' water, two catalytically important water molecules in the active site of the molecule. Both the azide and the bromide ions bind in a distorted tetrahedral manner 0.4 and 1.1 A from the zinc water position, respectively, but are in close contact (2.0 and 2.6 A, respectively) with the zinc ion. | ||
==Disease== | ==Disease== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Hakansson, K.]] | [[Category: Hakansson, K.]] | ||
[[Category: Jonsson, B | [[Category: Jonsson, B M.]] | ||
[[Category: Liljas, A.]] | [[Category: Liljas, A.]] | ||
[[Category: BR]] | [[Category: BR]] | ||
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[[Category: lyase(oxo-acid)]] | [[Category: lyase(oxo-acid)]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:48:59 2008'' | ||