1r2b: Difference between revisions
New page: left|200px<br /> <applet load="1r2b" size="450" color="white" frame="true" align="right" spinBox="true" caption="1r2b, resolution 2.2Å" /> '''Crystal structure of... |
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'''Crystal structure of the BCL6 BTB domain complexed with a SMRT co-repressor peptide'''<br /> | '''Crystal structure of the BCL6 BTB domain complexed with a SMRT co-repressor peptide'''<br /> | ||
==Overview== | ==Overview== | ||
BCL6 encodes a transcription factor that represses genes necessary for the | BCL6 encodes a transcription factor that represses genes necessary for the terminal differentiation of lymphocytes within germinal centers, and the misregulated expression of this factor is strongly implicated in several types of B cell lymphoma. The homodimeric BTB domain of BCL6 (also known as the POZ domain) is required for the repression activity of the protein and interacts directly with the SMRT and N-CoR corepressors that are found within large multiprotein histone deacetylase-containing complexes. We have identified a 17 residue fragment from SMRT that binds to the BCL6 BTB domain, and determined the crystal structure of the complex to 2.2 A. Two SMRT fragments bind symmetrically to the BCL6 BTB homodimer and, in combination with biochemical and in vivo data, the structure provides insight into the basis of transcriptional repression by this critical B cell lymphoma protein. | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
1R2B is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | 1R2B is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R2B OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Ahmad, K | [[Category: Ahmad, K F.]] | ||
[[Category: Bouchard, D.]] | [[Category: Bouchard, D.]] | ||
[[Category: Kiang, C | [[Category: Kiang, C L.]] | ||
[[Category: Lax, S | [[Category: Lax, S A.]] | ||
[[Category: Licht, J | [[Category: Licht, J D.]] | ||
[[Category: Liu, J.]] | [[Category: Liu, J.]] | ||
[[Category: Mayer, S.]] | [[Category: Mayer, S.]] | ||
[[Category: Melnick, A.]] | [[Category: Melnick, A.]] | ||
[[Category: Prive, G | [[Category: Prive, G G.]] | ||
[[Category: b-cell lymphoma]] | [[Category: b-cell lymphoma]] | ||
[[Category: btb domain]] | [[Category: btb domain]] | ||
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[[Category: transcriptional repression]] | [[Category: transcriptional repression]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:46:14 2008'' | ||
Revision as of 15:46, 21 February 2008
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Crystal structure of the BCL6 BTB domain complexed with a SMRT co-repressor peptide
OverviewOverview
BCL6 encodes a transcription factor that represses genes necessary for the terminal differentiation of lymphocytes within germinal centers, and the misregulated expression of this factor is strongly implicated in several types of B cell lymphoma. The homodimeric BTB domain of BCL6 (also known as the POZ domain) is required for the repression activity of the protein and interacts directly with the SMRT and N-CoR corepressors that are found within large multiprotein histone deacetylase-containing complexes. We have identified a 17 residue fragment from SMRT that binds to the BCL6 BTB domain, and determined the crystal structure of the complex to 2.2 A. Two SMRT fragments bind symmetrically to the BCL6 BTB homodimer and, in combination with biochemical and in vivo data, the structure provides insight into the basis of transcriptional repression by this critical B cell lymphoma protein.
DiseaseDisease
Known diseases associated with this structure: Diabetes mellitus, neonatal, with congenital hypothyroidism OMIM:[610192], Lymphoma, B-cell OMIM:[109565]
About this StructureAbout this Structure
1R2B is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain., Ahmad KF, Melnick A, Lax S, Bouchard D, Liu J, Kiang CL, Mayer S, Takahashi S, Licht JD, Prive GG, Mol Cell. 2003 Dec;12(6):1551-64. PMID:14690607
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