1qz8: Difference between revisions
New page: left|200px<br /><applet load="1qz8" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qz8, resolution 2.70Å" /> '''Crystal structure of... |
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[[Image:1qz8.gif|left|200px]]<br /><applet load="1qz8" size=" | [[Image:1qz8.gif|left|200px]]<br /><applet load="1qz8" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1qz8, resolution 2.70Å" /> | caption="1qz8, resolution 2.70Å" /> | ||
'''Crystal structure of SARS coronavirus NSP9'''<br /> | '''Crystal structure of SARS coronavirus NSP9'''<br /> | ||
==Overview== | ==Overview== | ||
The recently identified etiological agent of the severe acute respiratory | The recently identified etiological agent of the severe acute respiratory syndrome (SARS) belongs to Coronaviridae (CoV), a family of viruses replicating by a poorly understood mechanism. Here, we report the crystal structure at 2.7-A resolution of nsp9, a hitherto uncharacterized subunit of the SARS-CoV replicative polyproteins. We show that SARS-CoV nsp9 is a single-stranded RNA-binding protein displaying a previously unreported, oligosaccharide/oligonucleotide fold-like fold. The presence of this type of protein has not been detected in the replicative complexes of RNA viruses, and its presence may reflect the unique and complex CoV viral replication/transcription machinery. | ||
==About this Structure== | ==About this Structure== | ||
1QZ8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_sars_coronavirus Human sars coronavirus] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 1QZ8 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_sars_coronavirus Human sars coronavirus] with <scene name='pdbligand=SO4:'>SO4</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QZ8 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Canard, B.]] | [[Category: Canard, B.]] | ||
[[Category: Dutartre, H.]] | [[Category: Dutartre, H.]] | ||
[[Category: Egloff, M | [[Category: Egloff, M P.]] | ||
[[Category: Ferron, F.]] | [[Category: Ferron, F.]] | ||
[[Category: Gorbalenya, A | [[Category: Gorbalenya, A E.]] | ||
[[Category: Longhi, S.]] | [[Category: Longhi, S.]] | ||
[[Category: Rancurel, C.]] | [[Category: Rancurel, C.]] | ||
[[Category: Snijder, E | [[Category: Snijder, E J.]] | ||
[[Category: SO4]] | [[Category: SO4]] | ||
[[Category: coronavirus]] | [[Category: coronavirus]] | ||
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[[Category: sars]] | [[Category: sars]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:45:19 2008'' | ||
Revision as of 15:45, 21 February 2008
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Crystal structure of SARS coronavirus NSP9
OverviewOverview
The recently identified etiological agent of the severe acute respiratory syndrome (SARS) belongs to Coronaviridae (CoV), a family of viruses replicating by a poorly understood mechanism. Here, we report the crystal structure at 2.7-A resolution of nsp9, a hitherto uncharacterized subunit of the SARS-CoV replicative polyproteins. We show that SARS-CoV nsp9 is a single-stranded RNA-binding protein displaying a previously unreported, oligosaccharide/oligonucleotide fold-like fold. The presence of this type of protein has not been detected in the replicative complexes of RNA viruses, and its presence may reflect the unique and complex CoV viral replication/transcription machinery.
About this StructureAbout this Structure
1QZ8 is a Single protein structure of sequence from Human sars coronavirus with as ligand. Full crystallographic information is available from OCA.
ReferenceReference
The severe acute respiratory syndrome-coronavirus replicative protein nsp9 is a single-stranded RNA-binding subunit unique in the RNA virus world., Egloff MP, Ferron F, Campanacci V, Longhi S, Rancurel C, Dutartre H, Snijder EJ, Gorbalenya AE, Cambillau C, Canard B, Proc Natl Acad Sci U S A. 2004 Mar 16;101(11):3792-6. Epub 2004 Mar 8. PMID:15007178
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