Sandbox 645: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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 =='''Mechanism'''==
-Based on the hydrolysis mechanism. Water gets hydrolyzed by one of the aspartate residues , which leads to the formation of a tetrahedral oxyanion intermediate. This intermediate is formed by the water attack on the peptide carbonyl carbon.  Rearrangement leads to the protonation of the scissile amide and thus cleavage.
 [[Image:Mechanism aspartyl protease.png|500 px]]
 Mechanism for HIV-1 Protease