Sandbox 645: Difference between revisions
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*HIV Drugs: | *HIV Drugs: | ||
[[Image:Saquin1.gif|thumb|Saquinavir mesylate is a white to off-white, very fine powder with an aqueous solubility of 2.22 mg/mL at 25°C.]] | |||
1) Saquinavir (Invirase) is known to be one of the first FDA approved protease inhibitor for HIV treatment. This usually occurs by HIV protease binding an active site tunnel tightly, which will prevent polyproteins from also binding. HIV’s chemical structure has the ability to mimic the tetrahedral intermediate of the hydrolytic reaction to interact strong with the catalytic Asp residues. Knowing that, Saquinavir is an uncleavable ligand by studying its similar conformational changes in binding saquinavir or a polypeptide. ((http://www.rxlist.com/invirase-drug.htm)))) | |||
[[Image:Indinav1.gif|frame|Ritonavir molecular weight of 711.88. It is very soluble in water and in methanol.]] | |||
2) Indinavir (Crixivan) this protease inhibitor is an oral medication that blocks the protease activity and leads to defect the viruses. Once these viruses are unable to reach the body’s cells, it will decrease in number. This inhibitor doesn’t have the ability to prevent the HIV transmission among individuals, nor does it cure AIDS or HIV infection. Indinavir is approved by the FDA in March 1995. ((((http://www.medicinenet.com/indinavir/article.htm ))) | 2) Indinavir (Crixivan) this protease inhibitor is an oral medication that blocks the protease activity and leads to defect the viruses. Once these viruses are unable to reach the body’s cells, it will decrease in number. This inhibitor doesn’t have the ability to prevent the HIV transmission among individuals, nor does it cure AIDS or HIV infection. Indinavir is approved by the FDA in March 1995. ((((http://www.medicinenet.com/indinavir/article.htm ))) | ||
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[[Image:Ritonavirsol1.gif|frame|Ritonavir soluble in isopropanol and practically insoluble in water.]] | |||
3) Ritonavir (Norvir), has the same effect of indinavir on HIV protease. It was approved by the FDA in June 1999. This drug consists of capsules or tablets 100 mg; Solution: 80 mg/ml. It is recommended that adults consume 600 mg twice a day and then increase by 100 mg in every 2 days. Ritonavir can interact with many drugs leading those drugs to increase or decrease in effectiveness. It increases the concentration of Mycobutin and Viagra; however, decrease the concentration of Demerol. ((((http://www.medicinenet.com/ritonavir/article.htm)))) | |||
[[Image:Nelfin1.gif|frame|Nelfinavir is slightly soluble in water at pH ≤ 4 and completely soluble in methanol.]] | |||
4) Nelfinavir (Viracept), Nelfinavir was approved by the FDA in March, 1997. Nelfinavir has not been effectively evaluated in pregnant women. Viracept prevents T-cells that have been infected with HIV from producing new HIV. Usually given to patients through tablets. Each tablet contains inactive ingredients such as: calcium silicate, magnesium stearate, hypromellose, and triacetin. ( Picture ) http://www.rxlist.com/viracept-drug.htm | |||
4) Nelfinavir (Viracept), Nelfinavir was approved by the FDA in March, 1997. Nelfinavir has not been effectively evaluated in pregnant women. Viracept prevents T-cells that have been infected with HIV from producing new HIV. Usually given to patients through tablets. Each tablet contains inactive ingredients such as: calcium silicate, magnesium stearate, hypromellose, and triacetin. ( Picture ) http://www.rxlist.com/viracept-drug.htm | |||
((http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001007/)) | ((http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001007/)) | ||