Sandbox 645: Difference between revisions

← Older edit Newer edit →

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Ashraf Hasasneh, Tahreer Mutair, Charles Short

Revision as of 17:38, 26 November 2012 view source Ashraf Hasasneh (talk \| contribs) 37 edits →‎HIV-1 Protease ← Older edit		Revision as of 17:40, 26 November 2012 view source Ashraf Hasasneh (talk \| contribs) 37 edits →‎HIV-1 Protease Newer edit →
Line 16:		Line 16:
	HIV Drugs:		HIV Drugs:

	1) Saquinavir (Invirase) is known to be one of the first FDA approved protease inhibitor for HIV treatment. This usually occurs by HIV protease binding an active site tunnel tightly, which will prevent polyproteins from also binding. HIV’s chemical structure has the ability to mimic the tetrahedral intermediate of the hydrolytic reaction to interact strong with the catalytic Asp residues. Knowing that, Saquinavir is an uncleavable ligand by studying its similar conformational changes in binding saquinavir or a polypeptide. ((http://www.rxlist.com/invirase-drug.htm)))) [[Image:Saquin1.gif\|~~frame~~\|Saquinavir mesylate is a white to off-white, very fine powder with an aqueous solubility of 2.22 mg/mL at 25°C.]]		1) Saquinavir (Invirase) is known to be one of the first FDA approved protease inhibitor for HIV treatment. This usually occurs by HIV protease binding an active site tunnel tightly, which will prevent polyproteins from also binding. HIV’s chemical structure has the ability to mimic the tetrahedral intermediate of the hydrolytic reaction to interact strong with the catalytic Asp residues. Knowing that, Saquinavir is an uncleavable ligand by studying its similar conformational changes in binding saquinavir or a polypeptide. ((http://www.rxlist.com/invirase-drug.htm)))) [[Image:Saquin1.gif\|thumb\|Saquinavir mesylate is a white to off-white, very fine powder with an aqueous solubility of 2.22 mg/mL at 25°C.]]