Sandbox Reserved 390: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
=='''Human topoisomerase IIbeta in complex with DNA and etoposide'''== | =='''Human topoisomerase IIbeta in complex with DNA and etoposide'''== | ||
<StructureSection load='3qx3' size='500' side='right' caption='Structure of the human topoisomeraseIIbcore-DNA cleavage complex stabilized by the anticancer drug etoposide. (PDB entry 3QX3)' scene=''> | <StructureSection load='3qx3' size='500' side='right' caption='Structure of the human topoisomeraseIIbcore-DNA cleavage complex stabilized by the anticancer drug etoposide. (PDB entry 3QX3)' scene=''> | ||
The purpose of this page is to explain a semisynthetic derivative of podophyllotoxin [[Image:PODO.png|thumb|right|50 px|Chemical structure of podophyllotoxin]] (etoposide) that demonstrates antitumor activity by inhibiting DNA topoisomerase II, thereby inhibiting DNA re-ligation which lead to apoptosis of the cancer cell and also, to describe the mechanisms of resistance of etoposide. | The purpose of this page is to explain a semisynthetic derivative of [http://en.wikipedia.org/wiki/Podophyllotoxin podophyllotoxin] [[Image:PODO.png|thumb|right|50 px|Chemical structure of podophyllotoxin]] (etoposide) that demonstrates antitumor activity by inhibiting DNA topoisomerase II, thereby inhibiting DNA re-ligation which lead to apoptosis of the cancer cell and also, to describe the mechanisms of resistance of etoposide. | ||
__TOC__ | __TOC__ | ||
==INTRODUCTION == | ==INTRODUCTION == | ||