1cfp: Difference between revisions
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Revision as of 15:54, 30 October 2007
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S100B (S100BETA) NMR DATA WAS COLLECTED FROM A SAMPLE OF CALCIUM FREE PROTEIN AT PH 6.3 AND A TEMPERATURE OF 311 K AND 1.7-6.9 MM CONCENTRATION, 25 STRUCTURES
OverviewOverview
BACKGROUND. S100B (S100beta) is a member of the S100 family of small, calcium-binding proteins: members of this family contain two, helix-loop-helix calcium-binding motifs and interact with a wide range of, proteins involved mainly in the cytoskeleton and cell proliferation. S100B, is a neurite-extension factor and levels of S100B are elevated in the, brains of patients with Alzheimer's disease or Down's syndrome: the, pattern of S100B overexpression in Alzheimer's disease correlates with the, pattern of neuritic-plaque formation. Identification of a growing class of, S100 proteins and the likely neurochemical importance of S100B make the, determination of the structure of S100B of interest. RESULTS. We have used, NMR to determine the structure of the reduced S100B homodimer in the, ... [(full description)]
About this StructureAbout this Structure
1CFP is a [Single protein] structure of sequence from [Bos taurus]. Structure known Active Sites: LOA, LOB, LOC and LOD. Full crystallographic information is available from [OCA].
ReferenceReference
The solution structure of the bovine S100B protein dimer in the calcium-free state., Kilby PM, Van Eldik LJ, Roberts GC, Structure. 1996 Sep 15;4(9):1041-52. PMID:8805590
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