1qh2: Difference between revisions
New page: left|200px<br /><applet load="1qh2" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qh2" /> '''CHYMOTRYPSIN INHIBITOR (C2) FROM NICOTIANA A... |
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[[Image:1qh2.jpg|left|200px]]<br /><applet load="1qh2" size=" | [[Image:1qh2.jpg|left|200px]]<br /><applet load="1qh2" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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'''CHYMOTRYPSIN INHIBITOR (C2) FROM NICOTIANA ALATA'''<br /> | '''CHYMOTRYPSIN INHIBITOR (C2) FROM NICOTIANA ALATA'''<br /> | ||
==Overview== | ==Overview== | ||
Female reproductive tissues of the ornamental tobacco amass high levels of | Female reproductive tissues of the ornamental tobacco amass high levels of serine proteinase inhibitors (PIs) for protection against pests and pathogens. These PIs are produced from a precursor protein composed of six repeats each with a protease reactive site. Here we show that proteolytic processing of the precursor generates five single-chain PIs and a remarkable two-chain inhibitor formed by disulfide-bond linkage of N- and C-terminal peptide fragments. Surprisingly, PI precursors adopt this circular structure regardless of the number of inhibitor domains, suggesting this bracelet-like conformation is characteristic of the widespread potato inhibitor II (Pot II) protein family. | ||
==About this Structure== | ==About this Structure== | ||
1QH2 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Nicotiana_alata Nicotiana alata]. Full crystallographic information is available from [http:// | 1QH2 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Nicotiana_alata Nicotiana alata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QH2 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Nicotiana alata]] | [[Category: Nicotiana alata]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Anderson, M | [[Category: Anderson, M A.]] | ||
[[Category: Craik, D | [[Category: Craik, D J.]] | ||
[[Category: Lee, M | [[Category: Lee, M C.S.]] | ||
[[Category: Scanlon, M | [[Category: Scanlon, M J.]] | ||
[[Category: nicotiana alata]] | [[Category: nicotiana alata]] | ||
[[Category: potato ii trypsin inhibitor]] | [[Category: potato ii trypsin inhibitor]] | ||
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[[Category: serine proteinase inhibitor]] | [[Category: serine proteinase inhibitor]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:39:26 2008'' | ||
Revision as of 15:39, 21 February 2008
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CHYMOTRYPSIN INHIBITOR (C2) FROM NICOTIANA ALATA
OverviewOverview
Female reproductive tissues of the ornamental tobacco amass high levels of serine proteinase inhibitors (PIs) for protection against pests and pathogens. These PIs are produced from a precursor protein composed of six repeats each with a protease reactive site. Here we show that proteolytic processing of the precursor generates five single-chain PIs and a remarkable two-chain inhibitor formed by disulfide-bond linkage of N- and C-terminal peptide fragments. Surprisingly, PI precursors adopt this circular structure regardless of the number of inhibitor domains, suggesting this bracelet-like conformation is characteristic of the widespread potato inhibitor II (Pot II) protein family.
About this StructureAbout this Structure
1QH2 is a Protein complex structure of sequences from Nicotiana alata. Full crystallographic information is available from OCA.
ReferenceReference
A novel two-chain proteinase inhibitor generated by circularization of a multidomain precursor protein., Lee MC, Scanlon MJ, Craik DJ, Anderson MA, Nat Struct Biol. 1999 Jun;6(6):526-30. PMID:10360353
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