4d83: Difference between revisions
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[[Image:4d83.jpg|left|200px]] | |||
{{STRUCTURE_4d83| PDB=4d83 | SCENE= }} | |||
===Crystal Structure of Human Beta Secretase in Complex with NVP-BUR436, derived from a co-crystallization experiment=== | |||
{{ABSTRACT_PUBMED_22380629}} | |||
==About this Structure== | |||
[[4d83]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D83 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:021388807</ref><references group="xtra"/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Memapsin 2]] | |||
[[Category: Bourgier, E.]] | |||
[[Category: Rondeau, J M.]] | |||
[[Category: Alzheimer's disease]] | |||
[[Category: Aspartic proteinase]] | |||
[[Category: Bace1]] | |||
[[Category: Beta-secretase]] | |||
[[Category: Enzyme inhibitor complex]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
[[Category: Memapsin2]] | |||
[[Category: Structure-based drug design]] | |||
Revision as of 12:26, 21 November 2012
Crystal Structure of Human Beta Secretase in Complex with NVP-BUR436, derived from a co-crystallization experimentCrystal Structure of Human Beta Secretase in Complex with NVP-BUR436, derived from a co-crystallization experiment
Template:ABSTRACT PUBMED 22380629
About this StructureAbout this Structure
4d83 is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Rueeger H, Rondeau JM, McCarthy C, Mobitz H, Tintelnot-Blomley M, Neumann U, Desrayaud S. Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors. Bioorg Med Chem Lett. 2011 Apr 1;21(7):1942-7. Epub 2011 Feb 15. PMID:21388807 doi:10.1016/j.bmcl.2011.02.038