Tubulin: Difference between revisions
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[[Image:1z5w.png|left|200px|thumb|Crystal Structure of Tubulin [[1z5w]]]] | [[Image:1z5w.png|left|200px|thumb|Crystal Structure of Tubulin [[1z5w]]]] | ||
{{STRUCTURE_1z5w| PDB=1z5w | SIZE=300| SCENE=Tubulin/Cv/1 |right|CAPTION= | {{STRUCTURE_1z5w| PDB=1z5w | SIZE=300| SCENE=Tubulin/Cv/1 |right|CAPTION= γ-tubulin complex with GTP and Mg+2 ion (green), [[1z5w]] }} | ||
[[Tubulin]] (TUB) is a constituent of microtubules in eukaryotes. Microtubules are assembled from dimers of α-tubulin (TUBA) and β-tubulin (TUBB) bound to GTP. γ-tubulin (TUBG) is part of the nucleation of microtubules. Human TUB contains several numbered subtypes. FtsZ (Filamenting temperature-sensitive mutant Z) is a prokaryotic homologue of TUB. The images at the left and at the right correspond to one representative Tubulin, ''i.e.'' the crystal structure of Tubulin ([[1z5w]]). | [[Tubulin]] (TUB) is a constituent of microtubules in eukaryotes. Microtubules are assembled from dimers of α-tubulin (TUBA) and β-tubulin (TUBB) bound to GTP. γ-tubulin (TUBG) is part of the nucleation of microtubules. Human TUB contains several numbered subtypes. FtsZ (Filamenting temperature-sensitive mutant Z) is a prokaryotic homologue of TUB. The images at the left and at the right correspond to one representative Tubulin, ''i.e.'' the crystal structure of Tubulin ([[1z5w]]). | ||
Revision as of 16:06, 18 November 2012
Tubulin (TUB) is a constituent of microtubules in eukaryotes. Microtubules are assembled from dimers of α-tubulin (TUBA) and β-tubulin (TUBB) bound to GTP. γ-tubulin (TUBG) is part of the nucleation of microtubules. Human TUB contains several numbered subtypes. FtsZ (Filamenting temperature-sensitive mutant Z) is a prokaryotic homologue of TUB. The images at the left and at the right correspond to one representative Tubulin, i.e. the crystal structure of Tubulin (1z5w).
3D Structures of Tubulin3D Structures of Tubulin
TubulinTubulin
α-tubulinα-tubulin
2bto – PdTUBA+thioredoxin 1 – Prosthecobacter dejongeii
α-tubulin + β-tubulinα-tubulin + β-tubulin
3hkb, 3hkc, 3hkd, 3hke, 3n2g, 3n2k – sTUBA+sTUBB+stathmin-like protein B3 – sheep
3ryc, 3ryf, 3ryh, 3ryi - sTUBA+sTUBB+stathmin-4
2wbe – cTUBA1D+cTUBB2B+kinesin+AMPPNP – cow
3dco - cTUBA+cTUBB+kinesin-like NOD
1tvk - cTUBA+cTUBB+GDP+GTP+Epothilone A – electron crystallography
3iz0 - cTUBA+cTUBB+hNDC80/SPC25+hNUF2/SPC24 – electron microscopy
3edl - cTUBA1D+cTUBB2B+kinesin motor domain
2xrp - cTUBA1D+cTUBB2B+doublecortin
3du7, 3e22, 1z2b, 1sa0, 1sa1 – cTUBA1C+cTUBB2B+stathmin-like protein B3
1ffx - cTUBA+cTUBB+stathmin-like protein B3
1jff - cTUBA+cTUBB
2p4n - hTUBA+hTUBB+kinesin heavy chain
2hxf - pTUBA+pTUBB+kinesin-like KIF1A+AMPPNP – pig
2hxh - pTUBA+pTUBB+kinesin-like KIF1A+ADP
1ia0 - pTUBA+pTUBB+kinesin-like KIF1A+ATP
1tub - pTUBA+pTUBB – electron diffraction
2btq – PdTUBA+PdTUBB
γ-tubulinγ-tubulin
3cb2 – hTUBG1+GDP
1z5v - hTUBG1+GTPgS
1z5w - hTUBG1+GTP
FtsZFtsZ
2rhh, 2rhj – BsFtsZ+SO4 – Bacillus subtilis
2rhl - BsFtsZ+GDP
2rho - BsFtsZ+GDP+GTP-gamma-S
2vxy, 2vam – BsFtsZ
2ve8 – PaFtsZ gamma domain – Pseudomonas aeruginosa
2ve9 - PaFtsZ gamma domain+DNA
2vaw – PaFtsZ+GDP
1ofu - PaFtsZ+SULA
2r75 - AaFtsZ+8-morpholino-GTP – Aquifex aeolicus
2r6r - AaFtsZ
2q1x, 1rq2 - MtFtsZ+citrate – Mycobacterium tuberculosis
2q1y, 1rlu - MtFtsZ+GTP-gamma-S
1rq7 - MtFtsZ+GDP
2vap – MjFtsZ+GDP – Methancaldococcus jannaschii
1w58 - MjFtsZ+GMPCPP
1w59, 1fsz – MjFtsZ
1w5a - MjFtsZ+MgGTP
1w5b - MjFtsZ+GTP
1w5e, 1w5f – MjFtsZ (mutant)