Telomerase 3D structures: Difference between revisions
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[[Image:Tert.png|left|200px|thumb|Structure of the catalytic subunit of telomerase, TERT, [[3du5]]]] | [[Image:Tert.png|left|200px|thumb|Structure of the catalytic subunit of telomerase, TERT, [[3du5]]]] | ||
{{ | {{STRUCTURE_2r4g| PDB=2r4g | SIZE=400| SCENE= |right|CAPTION=RNA-binding domain of telomerase complex with Br- ions, [[2r4g]] }} | ||
[[Telomerase]] (TEL) adds DNA repeats to the tail end of telomeres. It carries its own RNA. The human TEL is composed of 2 [[Telomerase Reverse Transcriptase]] (TERT), 2 Telomerase RNA (TERC) and 2 dyskerin (DKC1) molecules. The images at the left and at the right correspond to one representative Telomerase structure, ''i.e.'' crystal structure of catalytic subunit of telomerase, TERT, from ''Tribolium castaneum'' ([[3du5]]). | [[Telomerase]] (TEL) adds DNA repeats to the tail end of telomeres. It carries its own RNA. The human TEL is composed of 2 [[Telomerase Reverse Transcriptase]] (TERT), 2 Telomerase RNA (TERC) and 2 dyskerin (DKC1) molecules. The images at the left and at the right correspond to one representative Telomerase structure, ''i.e.'' crystal structure of catalytic subunit of telomerase, TERT, from ''Tribolium castaneum'' ([[3du5]]). | ||
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[[3kyl]], [[3du5]], [[3du6]] – TERT+DNA – ''Tribolium castaneum''<br /> | [[3kyl]], [[3du5]], [[3du6]] – TERT+DNA – ''Tribolium castaneum''<br /> | ||
[[2r4g]] – TtTERT RNA binding domain | [[2r4g]] – TtTERT RNA binding domain – ''Tetrahymena thermophila''<br /> | ||
[[2b2a]] – TtTERT (mutant)<br /> | [[2b2a]] – TtTERT (mutant)<br /> | ||
[[2fey]] - TtTERC RNA P2b hairpin – NMR<br /> | [[2fey]] - TtTERC RNA P2b hairpin – NMR<br /> | ||
Revision as of 12:56, 18 November 2012
Telomerase (TEL) adds DNA repeats to the tail end of telomeres. It carries its own RNA. The human TEL is composed of 2 Telomerase Reverse Transcriptase (TERT), 2 Telomerase RNA (TERC) and 2 dyskerin (DKC1) molecules. The images at the left and at the right correspond to one representative Telomerase structure, i.e. crystal structure of catalytic subunit of telomerase, TERT, from Tribolium castaneum (3du5).
3D Structures of Telomerase3D Structures of Telomerase
3kyl, 3du5, 3du6 – TERT+DNA – Tribolium castaneum
2r4g – TtTERT RNA binding domain – Tetrahymena thermophila
2b2a – TtTERT (mutant)
2fey - TtTERC RNA P2b hairpin – NMR
1q75, 2k96 – hTERC RNA P2b hairpin (mutant) – human – NMR
2k95 - hTERC RNA P2b hairpin – NMR
2qh2 - hTERC RNA CR7– NMR
1na2, 1ymo - hTERC RNAstem loop IV– NMR
1z31 - hTERC RNA Pj6 hairpin – NMR