RA Mediated T-reg Differentiation: Difference between revisions
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=== RXRα-DNA Interactions === | === RXRα-DNA Interactions === | ||
RXRα homodimers preferrentially assemble on DR-1 repeat sequences. DR-1 sequences are composed of an AGGTCA tandem repeat, with a single nucleotide spacer in between the repeats. Only four residues, Lys22, Lys26, Glu19 and Arg27 interact with the DNA bases directly. Seven residues interact with the phosphate backbone of the DNA molecule, making sure it is in position for base recognition. | RXRα homodimers preferrentially assemble on DR-1 repeat sequences. DR-1 sequences are composed of an AGGTCA tandem repeat, with a single nucleotide spacer in between the repeats. Only <scene name='RA_Mediated_T-reg_Differentiaition/Rxr-dna_base_interact/1'>four residues,</scene> Lys22, Lys26, Glu19 and Arg27 interact with the DNA bases directly. <scene name='RA_Mediated_T-reg_Differentiaition/Rxr-dna_backbone_interact/1'>Seven residues</scene> interact with the phosphate backbone of the DNA molecule, making sure it is in position for base recognition. | ||
RXRα homodimers have also been shown to assemble on DR-2 tandem repeats, sequences with the same organization as DR-1, but with two nucleotides as a spacer. The DNA interaction is similar with DR-2 repeats, just spaced further apart. <ref> PMID: 10669605 </ref> | RXRα homodimers have also been shown to assemble on DR-2 tandem repeats, sequences with the same organization as DR-1, but with two nucleotides as a spacer. The DNA interaction is similar with DR-2 repeats, just spaced further apart. <ref> PMID: 10669605 </ref> | ||