Sandbox Reserved 644: Difference between revisions
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Levels of urea cycle intermediates may be decreased, as carbamoyl phosphate cannot replenish the cycle. The carbamoyl phosphate instead goes into the uridine monophosphate synthetic pathway. Here orotic acid (one step of this alternative pathway) levels in the blood are increased. | Levels of urea cycle intermediates may be decreased, as carbamoyl phosphate cannot replenish the cycle. The carbamoyl phosphate instead goes into the uridine monophosphate synthetic pathway. Here orotic acid (one step of this alternative pathway) levels in the blood are increased. | ||
A potential treatment for the high ammonia levels is to give sodium benzoate, which combines with glycine to produce hippurate, at the same time removing an ammonium group. Biotin also plays an important role in the functioning of the OTC enzyme [1] and has been shown to reduce ammonia intoxication in animal experiment. | A potential treatment for the high ammonia levels is to give sodium benzoate, which combines with glycine to produce hippurate, at the same time removing an ammonium group. Biotin also plays an important role in the functioning of the OTC enzyme [1] and has been shown to reduce ammonia intoxication in animal experiment. | ||
<scene name='Sandbox_Reserved_644/Active_site/1'>active sites</scene> | <scene name='Sandbox_Reserved_644/Active_site/1'>active sites</scene> | ||