1qa6: Difference between revisions
New page: left|200px<br /><applet load="1qa6" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qa6, resolution 2.800Å" /> '''CRYSTAL STRUCTURE O... |
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[[Image:1qa6.gif|left|200px]]<br /><applet load="1qa6" size=" | [[Image:1qa6.gif|left|200px]]<br /><applet load="1qa6" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1qa6, resolution 2.800Å" /> | caption="1qa6, resolution 2.800Å" /> | ||
'''CRYSTAL STRUCTURE OF A CONSERVED RIBOSOMAL PROTEIN-RNA COMPLEX'''<br /> | '''CRYSTAL STRUCTURE OF A CONSERVED RIBOSOMAL PROTEIN-RNA COMPLEX'''<br /> | ||
==Overview== | ==Overview== | ||
The structure of a highly conserved complex between a 58-nucleotide domain | The structure of a highly conserved complex between a 58-nucleotide domain of large subunit ribosomal RNA and the RNA-binding domain of ribosomal protein L11 has been solved at 2.8 angstrom resolution. It reveals a precisely folded RNA structure that is stabilized by extensive tertiary contacts and contains an unusually large core of stacked bases. A bulge loop base from one hairpin of the RNA is intercalated into the distorted major groove of another helix; the protein locks this tertiary interaction into place by binding to the intercalated base from the minor groove side. This direct interaction with a key ribosomal RNA tertiary interaction suggests that part of the role of L11 is to stabilize an unusual RNA fold within the ribosome. | ||
==About this Structure== | ==About this Structure== | ||
1QA6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus] with MG and OS as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | 1QA6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus] with <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=OS:'>OS</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QA6 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Geobacillus stearothermophilus]] | [[Category: Geobacillus stearothermophilus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Conn, G | [[Category: Conn, G L.]] | ||
[[Category: Draper, D | [[Category: Draper, D E.]] | ||
[[Category: Gittis, A | [[Category: Gittis, A G.]] | ||
[[Category: Lattman, E | [[Category: Lattman, E E.]] | ||
[[Category: MG]] | [[Category: MG]] | ||
[[Category: OS]] | [[Category: OS]] | ||
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[[Category: tertiary structur]] | [[Category: tertiary structur]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:37:29 2008'' | ||
Revision as of 15:37, 21 February 2008
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CRYSTAL STRUCTURE OF A CONSERVED RIBOSOMAL PROTEIN-RNA COMPLEX
OverviewOverview
The structure of a highly conserved complex between a 58-nucleotide domain of large subunit ribosomal RNA and the RNA-binding domain of ribosomal protein L11 has been solved at 2.8 angstrom resolution. It reveals a precisely folded RNA structure that is stabilized by extensive tertiary contacts and contains an unusually large core of stacked bases. A bulge loop base from one hairpin of the RNA is intercalated into the distorted major groove of another helix; the protein locks this tertiary interaction into place by binding to the intercalated base from the minor groove side. This direct interaction with a key ribosomal RNA tertiary interaction suggests that part of the role of L11 is to stabilize an unusual RNA fold within the ribosome.
About this StructureAbout this Structure
1QA6 is a Single protein structure of sequence from Geobacillus stearothermophilus with and as ligands. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of a conserved ribosomal protein-RNA complex., Conn GL, Draper DE, Lattman EE, Gittis AG, Science. 1999 May 14;284(5417):1171-4. PMID:10325228
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