1q5c: Difference between revisions
New page: left|200px<br /><applet load="1q5c" size="450" color="white" frame="true" align="right" spinBox="true" caption="1q5c" /> '''S-S-lambda-shaped TRANS and CIS interactions... |
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[[Image:1q5c.gif|left|200px]]<br /><applet load="1q5c" size=" | [[Image:1q5c.gif|left|200px]]<br /><applet load="1q5c" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1q5c" /> | caption="1q5c" /> | ||
'''S-S-lambda-shaped TRANS and CIS interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography'''<br /> | '''S-S-lambda-shaped TRANS and CIS interactions of cadherins model based on fitting C-cadherin (1L3W) to 3D map of desmosomes obtained by electron tomography'''<br /> | ||
==Overview== | ==Overview== | ||
Cell adhesion by adherens junctions and desmosomes relies on interactions | Cell adhesion by adherens junctions and desmosomes relies on interactions between cadherin molecules. However, the molecular interfaces that define molecular specificity and that mediate adhesion remain controversial. We used electron tomography of plastic sections from neonatal mouse skin to visualize the organization of desmosomes in situ. The resulting three-dimensional maps reveal individual cadherin molecules forming discrete groups and interacting through their tips. Fitting of an x-ray crystal structure for C-cadherin to these maps is consistent with a flexible intermolecular interface mediated by an exchange of amino-terminal tryptophans. This flexibility suggests a novel mechanism for generating both cis and trans interactions and for propagating these adhesive interactions along the junction. | ||
==About this Structure== | ==About this Structure== | ||
1Q5C is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with NAG, NDG and CA as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | 1Q5C is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with <scene name='pdbligand=NAG:'>NAG</scene>, <scene name='pdbligand=NDG:'>NDG</scene> and <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Q5C OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Cowin, P.]] | [[Category: Cowin, P.]] | ||
[[Category: He, W.]] | [[Category: He, W.]] | ||
[[Category: Stokes, D | [[Category: Stokes, D L.]] | ||
[[Category: CA]] | [[Category: CA]] | ||
[[Category: NAG]] | [[Category: NAG]] | ||
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[[Category: cadherin; trans interaction; desmosome; junction; adhesion]] | [[Category: cadherin; trans interaction; desmosome; junction; adhesion]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:35:59 2008'' | ||
