Sandbox Reserved 644: Difference between revisions
No edit summary |
Nick Shimko (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
<!-- PLEASE DO NOT DELETE THIS TEMPLATE --> | /><!-- PLEASE DO NOT DELETE THIS TEMPLATE --> | ||
{{Sandbox_Reserved_Robert_B_Rose_2}} | {{Sandbox_Reserved_Robert_B_Rose_2}} | ||
<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | <!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
| Line 5: | Line 5: | ||
=='''Ornithine Transcarbamoylase'''== | =='''Ornithine Transcarbamoylase'''== | ||
===='''Introduction'''==== | ===='''Introduction'''==== | ||
<applet load='1c9y' size='500' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' | |||
Ornithine transcarbamoylase (OTC) is an enzyme that catalyzes the reaction between carbamoyl phosphate and ornithine to form citrulline and phosphate, and this occurs during the second step of the urea cycle. In plants and microbes, OTC is involved in arginine biosynthesis, but in mammals it is located in the mitochondria and is part of the urea cycle.<ref>http://en.wikipedia.org/wiki/Ornithine_transcarbamylase</ref> | Ornithine transcarbamoylase (OTC) is an enzyme that catalyzes the reaction between carbamoyl phosphate and ornithine to form citrulline and phosphate, and this occurs during the second step of the urea cycle. In plants and microbes, OTC is involved in arginine biosynthesis, but in mammals it is located in the mitochondria and is part of the urea cycle.<ref>http://en.wikipedia.org/wiki/Ornithine_transcarbamylase</ref> | ||
OTC is often associated with Ornithine transcarbamoylase deficiency (OTCD). OTCD is a common urea cycle disorder, and it is a genetic disorder which results in a mutated and ineffective form of the enzyme OTC. The gene is located on the short arm of chromosome X (Xp21.1). The gene is located in the Watson (plus) strand and is 68,968 bases in length. The encoded protein is 354 amino acids long with a predicted molecular weight of 39.935 kiloDaltons. The protein is located in the mitochondrial matrix.<ref>http://en.wikipedia.org/wiki/Ornithine_transcarbamylase</ref> | OTC is often associated with Ornithine transcarbamoylase deficiency (OTCD). OTCD is a common urea cycle disorder, and it is a genetic disorder which results in a mutated and ineffective form of the enzyme OTC. The gene is located on the short arm of chromosome X (Xp21.1). The gene is located in the Watson (plus) strand and is 68,968 bases in length. The encoded protein is 354 amino acids long with a predicted molecular weight of 39.935 kiloDaltons. The protein is located in the mitochondrial matrix.<ref>http://en.wikipedia.org/wiki/Ornithine_transcarbamylase</ref> | ||