RA Mediated T-reg Differentiation: Difference between revisions
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==Introduction== | ==Introduction== | ||
T-regulatory cells (T-regs) are a small subset of CD4+ T-cells that exhibit strong down regulation of immune system activity in their local environment. They are distinguished from other CD4+ T-cells by the expression of FOXP3, a gene regulator. | |||
<StructureSection load='1dq8' size='350' side='left' caption='RARα-RXRα interaction (PDB entry [[1dkf]])' scene=''> | <StructureSection load='1dq8' size='350' side='left' caption='RARα-RXRα interaction (PDB entry [[1dkf]])' scene=''> | ||
==Ligand Binding Domain== | ==Ligand Binding Domain== | ||
Revision as of 07:03, 7 November 2012
IntroductionIntroduction
T-regulatory cells (T-regs) are a small subset of CD4+ T-cells that exhibit strong down regulation of immune system activity in their local environment. They are distinguished from other CD4+ T-cells by the expression of FOXP3, a gene regulator.
| Ligand Binding DomainRARα-RXRα HeterodimerRARα-RXRα Ligand Interactions | ||||||||||
DNA Binding DomainRXRα-DNA InteractionsDR-5 Specificity |
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