Growth factor receptor-bound protein: Difference between revisions

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Revision as of 12:16, 4 November 2012 view source Michal Harel (talk \| contribs) 31,761 edits No edit summary ← Older edit		Revision as of 12:18, 4 November 2012 view source Michal Harel (talk \| contribs) 31,761 edits No edit summary Newer edit →
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	<StructureSection load='1tze' size='400' side='right' caption='Structure of human Grb2 SH2 domain complex with phosphotyrosyl ~~derivative~~ (PDB entry [[1tze]])' scene=''>		<StructureSection load='1tze' size='400' side='right' caption='Structure of human Grb2 SH2 domain (pink) complex with phosphotyrosyl heptapeptide (gold) (PDB entry [[1tze]])' scene=''>

	'''Growth factor receptor-bound protein 2''' (GRB2) is an adaptor protein. It links the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases. GRB2 contains an SH2 domain which binds tyrosine phosphorylated sequences and 2 SH3 domains which direct complex formation of proline-rich sequences. GRB2 is involved in signal transduction.		'''Growth factor receptor-bound protein 2''' (GRB2) is an adaptor protein. It links the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases. GRB2 contains an SH2 domain which binds tyrosine phosphorylated sequences and 2 SH3 domains which direct complex formation of proline-rich sequences. GRB2 is involved in signal transduction.