MtrF: Difference between revisions
Jump to navigation
Jump to search
David Canner (talk | contribs) No edit summary |
David Canner (talk | contribs) No edit summary |
||
| Line 11: | Line 11: | ||
==MtrF’s role in Diseases== | ==MtrF’s role in Diseases== | ||
''Neisseria gonorrhoeae'' is the bacteria that causes the STD gonorrhea. This bacteria is quite resistant to many hydrophobic drugs, detergents, and dyes. The reason behind the tough resistance is the energy dependent efflux pump Mtr (Multiple transferable resistance). MtrF has been identified as a cell envelope protein that is involved with the resistance of hydrophobic antimicrobials in ''Neisseria gonorrhoeae''. MtrF is a protein that helps highlight the expression of detergent resistance by ''Gonococci''. MtrF is thought to act in accordance with the MtrC- MtrD- MtrE efflux pump; to make sure ''Gonococci'' has high level resistance to specific hydrophobic agents. MtrF is located near the MtrR gene and is predicted to encode a cytoplasmic membrane protein that contains up to twelve transmembrane domains. The expression of MtrF is ultimately subject to MtrR’s transcriptional control. MtrF was given its name because it is so closely tied to the protein MtrR. Several orthologues were discovered in a few Gram-negative and positive bacteria, indicating that perhaps the predicted products may represent an undescribed protein family that is highly involved with resistance of antimicrobials. <ref> PMID:12493784 </ref> | ''Neisseria gonorrhoeae'' is the bacteria that causes the STD gonorrhea. This bacteria is quite resistant to many hydrophobic drugs, detergents, and dyes. The reason behind the tough resistance is the energy dependent efflux pump Mtr (Multiple transferable resistance). MtrF has been identified as a cell envelope protein that is involved with the resistance of hydrophobic antimicrobials in ''Neisseria gonorrhoeae''. MtrF is a protein that helps highlight the expression of detergent resistance by ''Gonococci''. MtrF is thought to act in accordance with the MtrC- MtrD- MtrE efflux pump; to make sure ''Gonococci'' has high level resistance to specific hydrophobic agents. MtrF is located near the MtrR gene and is predicted to encode a cytoplasmic membrane protein that contains up to twelve transmembrane domains. The expression of MtrF is ultimately subject to MtrR’s transcriptional control. MtrF was given its name because it is so closely tied to the protein MtrR. Several orthologues were discovered in a few Gram-negative and positive bacteria, indicating that perhaps the predicted products may represent an undescribed protein family that is highly involved with resistance of antimicrobials. <ref> PMID:12493784 </ref> | ||
==Regulation of MtrF== | ==Regulation of MtrF== | ||