Laccase: Difference between revisions
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[[2x87]], [[2x88]], [[1w6l]], [[1w6w]], [[1w8e]], [[1gsk]] – BsCotAl – ''Bacillus subtilis''<br /> | [[2x87]], [[2x88]], [[1w6l]], [[1w6w]], [[1w8e]], [[1gsk]] – BsCotAl – ''Bacillus subtilis''<br /> | ||
[[2bhf]] - BsCotAl reduced<br /> | [[2bhf]] - BsCotAl reduced<br /> | ||
[[2wsd]] – BsCotAl (mutant)<br /> | [[2wsd]], [[4ako]], [[4akp]], [[4akq]] – BsCotAl (mutant)<br /> | ||
[[1of0]] - BsCotAl + EBS<br /> | [[1of0]] - BsCotAl + EBS<br /> | ||
[[4a66]], [[4a67]], [[4a68]] - BsSCP (mutant) + Cu + peroxide<br /> | |||
[[1uvw]] - BsCotAl + ABTS | [[1uvw]] - BsCotAl + ABTS | ||
===CotS laccase=== | |||
[[1nps]] – CotSl N terminal – ''Myxococcus xanthus'' | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 11:20, 21 October 2012
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CotA laccase belong to the multi-copper oxidase family. The multi-copper oxidases constitute a family of enzymes whose principal members are laccase (benzenediol oxygen oxidoreductase, EC 1.10.3.2), ascorbate oxidase (L-ascorbate oxygen oxidoreductase, EC 1.10.3.3) and ceruloplasmin (Fe(II) oxygen oxidoreductase, EC 1.16.3.1). Similar to the other laccases the three dimensional struture of CotA 1w6l comprises three cupredoxin domain and four copper ions organised in : a and
The trinuclear center has two type 3 copper ions, that can be anti-ferromagnetically coupled through an hydroxyl moiety in between them, and one type 2 copper ion.‡ The mononuclear copper is able to accept an electron froma variety of phenolic substrates and then transmits it to the trinuclear centre.
3D structures of CotA laccase3D structures of CotA laccase
2x87, 2x88, 1w6l, 1w6w, 1w8e, 1gsk – BsCotAl – Bacillus subtilis
2bhf - BsCotAl reduced
2wsd, 4ako, 4akp, 4akq – BsCotAl (mutant)
1of0 - BsCotAl + EBS
4a66, 4a67, 4a68 - BsSCP (mutant) + Cu + peroxide
1uvw - BsCotAl + ABTS
CotS laccaseCotS laccase
1nps – CotSl N terminal – Myxococcus xanthus