1o0d: Difference between revisions
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==Overview== | ==Overview== | ||
Synthesis of thrombin inhibitors and their binding mode to thrombin is | Synthesis of thrombin inhibitors and their binding mode to thrombin is described. Modification of the P1 moiety leads to an increased selectivity versus trypsin. The observed selectivity is discussed in view of their thrombin-inhibitor complex X-ray structures. | ||
==Disease== | ==Disease== | ||
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[[Category: Thrombin]] | [[Category: Thrombin]] | ||
[[Category: Bauke, D.]] | [[Category: Bauke, D.]] | ||
[[Category: Hoeffken, H | [[Category: Hoeffken, H W.]] | ||
[[Category: Hornberger, W.]] | [[Category: Hornberger, W.]] | ||
[[Category: Lange, U | [[Category: Lange, U E.]] | ||
[[Category: Mack, H.]] | [[Category: Mack, H.]] | ||
[[Category: Seitz, W.]] | [[Category: Seitz, W.]] | ||
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[[Category: ternary complex; thrombin/active-site inhibitor/exo-site inhibitor]] | [[Category: ternary complex; thrombin/active-site inhibitor/exo-site inhibitor]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:12:00 2008'' | ||
Revision as of 15:12, 21 February 2008
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Human Thrombin complexed with a d-Phe-Pro-Arg-type Inhibitor and a C-terminal Hirudin derived exo-site inhibitor
OverviewOverview
Synthesis of thrombin inhibitors and their binding mode to thrombin is described. Modification of the P1 moiety leads to an increased selectivity versus trypsin. The observed selectivity is discussed in view of their thrombin-inhibitor complex X-ray structures.
DiseaseDisease
Known diseases associated with this structure: Dysprothrombinemia OMIM:[176930], Hyperprothrombinemia OMIM:[176930], Hypoprothrombinemia OMIM:[176930]
About this StructureAbout this Structure
1O0D is a Protein complex structure of sequences from Homo sapiens with as ligand. Active as Thrombin, with EC number 3.4.21.5 Full crystallographic information is available from OCA.
ReferenceReference
D-Phe-Pro-Arg type thrombin inhibitors: unexpected selectivity by modification of the P1 moiety., Lange UE, Baucke D, Hornberger W, Mack H, Seitz W, Hoffken HW, Bioorg Med Chem Lett. 2003 Jun 16;13(12):2029-33. PMID:12781189
Page seeded by OCA on Thu Feb 21 14:12:00 2008