1nhx: Difference between revisions
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==Overview== | ==Overview== | ||
The analysis of the X-ray structures of two xanthine inhibitors bound to | The analysis of the X-ray structures of two xanthine inhibitors bound to PEPCK and a comparison to the X-ray structure of GTP bound to PEPCK are reported. The SAR at N-1, N-7 and developing SAR at C-8 are consistent with information gained from the X-ray structures of compounds 1 and 2 bound to PEPCK. Representative N-3 modifications of compound 2 that led to the discovery of 3-cyclopropylmethyl and its carboxy analogue as optimal N-3 groups are presented. | ||
==Disease== | ==Disease== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Dunten, P.]] | [[Category: Dunten, P.]] | ||
[[Category: Foley, L | [[Category: Foley, L H.]] | ||
[[Category: Gubler, M | [[Category: Gubler, M L.]] | ||
[[Category: Ramsey, G.]] | [[Category: Ramsey, G.]] | ||
[[Category: Wang, P.]] | [[Category: Wang, P.]] | ||
[[Category: Wertheimer, S | [[Category: Wertheimer, S J.]] | ||
[[Category: EDO]] | [[Category: EDO]] | ||
[[Category: FTB]] | [[Category: FTB]] | ||
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[[Category: xanthine]] | [[Category: xanthine]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:06:22 2008'' | ||