2bim: Difference between revisions
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==About this Structure== | ==About this Structure== | ||
[[2bim]] is a 2 chain structure | [[2bim]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BIM OCA]. | ||
==See Also== | ==See Also== | ||
Revision as of 20:26, 20 October 2012
HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-N239Y-N268D-R273HHUMAN P53 CORE DOMAIN MUTANT M133L-V203A-N239Y-N268D-R273H
Template:ABSTRACT PUBMED 15703170
About this StructureAbout this Structure
2bim is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ Joerger AC, Ang HC, Veprintsev DB, Blair CM, Fersht AR. Structures of p53 cancer mutants and mechanism of rescue by second-site suppressor mutations. J Biol Chem. 2005 Apr 22;280(16):16030-7. Epub 2005 Feb 9. PMID:15703170 doi:http://dx.doi.org/10.1074/jbc.M500179200
- ↑ Joerger AC, Allen MD, Fersht AR. Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations. J Biol Chem. 2004 Jan 9;279(2):1291-6. Epub 2003 Oct 8. PMID:14534297 doi:10.1074/jbc.M309732200
- ↑ Cho Y, Gorina S, Jeffrey PD, Pavletich NP. Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. Science. 1994 Jul 15;265(5170):346-55. PMID:8023157
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OCACategories:
- Pages with broken file links
- Homo sapiens
- Fersht, A R.
- Joerger, A C.
- Activator
- Anti-oncogene
- Apoptosis
- Disease mutation
- Dna-binding
- Dna-binding protein
- Li-fraumeni syndrome
- Nuclear protein
- P53 dna-binding domain
- Phosphorylation
- Second-site suppressor mutation
- Superstable mutant
- Transcription regulation
- Transferase
- Tumor suppressor