1a3d: Difference between revisions
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Revision as of 15:39, 30 October 2007
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PHOSPHOLIPASE A2 (PLA2) FROM NAJA NAJA VENOM
OverviewOverview
Three crystal forms of Naja naja naja phospholipase A2 were discovered, through random crystallization screening, including two heretofore, uncharacterized forms. The crystallization conditions for both of these, novel crystal forms are Ca(2+)-free whereas previously reported conditions, include Ca2+. One of the new crystal forms has a cubic lattice in the, space group P2(1)3 (a = b = c = 69.24 A), the other has an orthorhombic, lattice in the space group P2(1)2(1)2(1) (a = 67.22 A, b = 73.48 A, c =, 87.52 A) and a previously characterized crystal belong to the tetragonal, space group P4(3)2(1)2 (a = b = 88.6 A, c = 107.4 A). The structure from, the cubic crystal form has been determined to 1.8 A and refined to an, R-factor of 17% while the structure from the orthorhombic form has been, ... [(full description)]
About this StructureAbout this Structure
1A3D is a [Single protein] structure of sequence from [Naja naja] with NA as [ligand]. Active as [Phospholipase A(2)], with EC number [3.1.1.4]. Structure known Active Site: CAB. Full crystallographic information is available from [OCA].
ReferenceReference
Structures of two novel crystal forms of Naja naja naja phospholipase A2 lacking Ca2+ reveal trimeric packing., Segelke BW, Nguyen D, Chee R, Xuong NH, Dennis EA, J Mol Biol. 1998 May 29;279(1):223-32. PMID:9636712
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