1n1l: Difference between revisions
New page: left|200px<br /><applet load="1n1l" size="450" color="white" frame="true" align="right" spinBox="true" caption="1n1l, resolution 2.60Å" /> '''CRYSTAL STRUCTURE OF... |
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[[Image:1n1l.jpg|left|200px]]<br /><applet load="1n1l" size=" | [[Image:1n1l.jpg|left|200px]]<br /><applet load="1n1l" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1n1l, resolution 2.60Å" /> | caption="1n1l, resolution 2.60Å" /> | ||
'''CRYSTAL STRUCTURE OF HCV NS3 PROTEASE DOMAIN:NS4A PEPTIDE COMPLEX WITH COVALENTLY BOUND INHIBITOR (GW472467X)'''<br /> | '''CRYSTAL STRUCTURE OF HCV NS3 PROTEASE DOMAIN:NS4A PEPTIDE COMPLEX WITH COVALENTLY BOUND INHIBITOR (GW472467X)'''<br /> | ||
==Overview== | ==Overview== | ||
[reaction: see text] In this, the second of two letters, we describe the | [reaction: see text] In this, the second of two letters, we describe the elaboration of the pyrrolidine-5,5-trans-lactam template to delineate the requirements for optimal substitution of the pyrrolidine and lactam nitrogen atoms. Central to the strategy is the use of rapid iterative synthesis in conjunction with X-ray crystal structure determination of ligand-protein complexes. | ||
==About this Structure== | ==About this Structure== | ||
1N1L is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus] with ZN and TRL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | 1N1L is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=TRL:'>TRL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N1L OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Hepatitis c virus]] | [[Category: Hepatitis c virus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Andrews, D | [[Category: Andrews, D M.]] | ||
[[Category: Chaignot, H.]] | [[Category: Chaignot, H.]] | ||
[[Category: Coomber, B | [[Category: Coomber, B A.]] | ||
[[Category: Good, A | [[Category: Good, A C.]] | ||
[[Category: Hind, S | [[Category: Hind, S L.]] | ||
[[Category: Jones, P | [[Category: Jones, P S.]] | ||
[[Category: Mill, G.]] | [[Category: Mill, G.]] | ||
[[Category: Robinson, J | [[Category: Robinson, J E.]] | ||
[[Category: Skarzynski, T.]] | [[Category: Skarzynski, T.]] | ||
[[Category: Slater, M | [[Category: Slater, M J.]] | ||
[[Category: Somers, D | [[Category: Somers, D O.N.]] | ||
[[Category: TRL]] | [[Category: TRL]] | ||
[[Category: ZN]] | [[Category: ZN]] | ||
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[[Category: viral protein]] | [[Category: viral protein]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:01:17 2008'' | ||
Revision as of 15:01, 21 February 2008
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CRYSTAL STRUCTURE OF HCV NS3 PROTEASE DOMAIN:NS4A PEPTIDE COMPLEX WITH COVALENTLY BOUND INHIBITOR (GW472467X)
OverviewOverview
[reaction: see text] In this, the second of two letters, we describe the elaboration of the pyrrolidine-5,5-trans-lactam template to delineate the requirements for optimal substitution of the pyrrolidine and lactam nitrogen atoms. Central to the strategy is the use of rapid iterative synthesis in conjunction with X-ray crystal structure determination of ligand-protein complexes.
About this StructureAbout this Structure
1N1L is a Protein complex structure of sequences from Hepatitis c virus with and as ligands. Full crystallographic information is available from OCA.
ReferenceReference
Pyrrolidine-5,5-trans-lactams. 2. The use of X-ray crystal structure data in the optimization of P3 and P4 substituents., Andrews DM, Chaignot H, Coomber BA, Good AC, Hind SL, Johnson MR, Jones PS, Mills G, Robinson JE, Skarzynski T, Slater MJ, Somers DO, Org Lett. 2002 Dec 12;4(25):4479-82. PMID:12465917
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