1n1f: Difference between revisions

Revision as of 15:01, 21 February 2008

Crystal Structure of Human Interleukin-19

OverviewOverview

Interleukin-19 (IL-19) is a novel cytokine that was initially identified during a sequence data base search aimed at finding potential IL-10 homologs. IL-19 shares a receptor complex with IL-20, indicating that the biological activities of these two cytokines overlap and that both may play an important role in regulating development and proper functioning of the skin. We determined the crystal structure of human recombinant IL-19 and refined it at 1.95-A resolution to an R-factor of 0.157. Unlike IL-10, which forms an intercalated dimer, the molecule of IL-19 is a monomer made of seven amphipathic helices, A-G, creating a unique helical bundle. On the basis of the observed structure, we propose that IL-19, IL-20, and other putative members of the proposed IL-10 family together form a distinct subfamily of helical cytokines.

About this StructureAbout this Structure

1N1F is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of interleukin-19 defines a new subfamily of helical cytokines., Chang C, Magracheva E, Kozlov S, Fong S, Tobin G, Kotenko S, Wlodawer A, Zdanov A, J Biol Chem. 2003 Jan 31;278(5):3308-13. Epub 2002 Oct 25. PMID:12403790

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 ==Overview==
-Interleukin-19 (IL-19) is a novel cytokine that was initially identified, during a sequence data base search aimed at finding potential IL-10, homologs. IL-19 shares a receptor complex with IL-20, indicating that the, biological activities of these two cytokines overlap and that both may, play an important role in regulating development and proper functioning of, the skin. We determined the crystal structure of human recombinant IL-19, and refined it at 1.95-A resolution to an R-factor of 0.157. Unlike IL-10, which forms an intercalated dimer, the molecule of IL-19 is a monomer made, of seven amphipathic helices, A-G, creating a unique helical bundle. On, the basis of the observed structure, we propose that IL-19, IL-20, and, other putative members of the proposed IL-10 family together form a, distinct subfamily of helical cytokines.
+Interleukin-19 (IL-19) is a novel cytokine that was initially identified during a sequence data base search aimed at finding potential IL-10 homologs. IL-19 shares a receptor complex with IL-20, indicating that the biological activities of these two cytokines overlap and that both may play an important role in regulating development and proper functioning of the skin. We determined the crystal structure of human recombinant IL-19 and refined it at 1.95-A resolution to an R-factor of 0.157. Unlike IL-10, which forms an intercalated dimer, the molecule of IL-19 is a monomer made of seven amphipathic helices, A-G, creating a unique helical bundle. On the basis of the observed structure, we propose that IL-19, IL-20, and other putative members of the proposed IL-10 family together form a distinct subfamily of helical cytokines.
 ==About this Structure==
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 [[Category: interleukin]]
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