1mp6: Difference between revisions
New page: left|200px<br /><applet load="1mp6" size="450" color="white" frame="true" align="right" spinBox="true" caption="1mp6" /> '''Structure of the transmembrane region of the... |
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[[Image:1mp6.jpg|left|200px]]<br /><applet load="1mp6" size=" | [[Image:1mp6.jpg|left|200px]]<br /><applet load="1mp6" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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'''Structure of the transmembrane region of the M2 protein H+ channel by solid state NMR spectroscopy'''<br /> | '''Structure of the transmembrane region of the M2 protein H+ channel by solid state NMR spectroscopy'''<br /> | ||
==Overview== | ==Overview== | ||
The transmembrane domain of the M2 protein from influenza A virus forms a | The transmembrane domain of the M2 protein from influenza A virus forms a nearly uniform and ideal helix in a liquid crystalline bilayer environment. The exposure of the hydrophilic backbone structure is minimized through uniform hydrogen bond geometry imposed by the low dielectric lipid environment. A high-resolution structure of the monomer backbone and a detailed description of its orientation with respect to the bilayer were achieved using orientational restraints from solid-state NMR. With this unique information, the tetrameric structure of this H(+) channel is constrained substantially. Features of numerous published models are discussed in light of the experimental structure of the monomer and derived features of the tetrameric bundle. | ||
==About this Structure== | ==About this Structure== | ||
1MP6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http:// | 1MP6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MP6 OCA]. | ||
==Reference== | ==Reference== | ||
Structure of the transmembrane region of the M2 protein H(+) channel., Wang J, Kim S, Kovacs F, Cross TA, Protein Sci. 2001 Nov;10(11):2241-50. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11604531 11604531] | Structure of the transmembrane region of the M2 protein H(+) channel., Wang J, Kim S, Kovacs F, Cross TA, Protein Sci. 2001 Nov;10(11):2241-50. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11604531 11604531] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Cross, T | [[Category: Cross, T A.]] | ||
[[Category: Kim, S.]] | [[Category: Kim, S.]] | ||
[[Category: Kovacs, F.]] | [[Category: Kovacs, F.]] | ||
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[[Category: solid state nmr]] | [[Category: solid state nmr]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:57:33 2008'' | ||
