1m7b: Difference between revisions
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==Overview== | ==Overview== | ||
The Rnd proteins constitute an exceptional subfamily within the Rho GTPase | The Rnd proteins constitute an exceptional subfamily within the Rho GTPase family. They possess extended chains at both termini and four prominent amino acid deviations causing GTPase deficiency. Herein, we report the crystal structure of the Rnd3/RhoE G-domain (amino acids 19-200) at 2.0 A resolution. This is the first GTP-structure of a Rho family member which reveals a similar fold but striking differences from RhoA concerning (i) GTPase center, (ii) charge distribution at several surface areas, (iii) C3-transferase binding site and (iv) interacting interfaces towards RhoA regulators and effectors. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Ahmadian, M | [[Category: Ahmadian, M R.]] | ||
[[Category: Blumenstein, L.]] | [[Category: Blumenstein, L.]] | ||
[[Category: Fiegen, D.]] | [[Category: Fiegen, D.]] | ||
[[Category: Stege, P.]] | [[Category: Stege, P.]] | ||
[[Category: Vetter, I | [[Category: Vetter, I R.]] | ||
[[Category: GTP]] | [[Category: GTP]] | ||
[[Category: MG]] | [[Category: MG]] | ||
[[Category: small gtpase]] | [[Category: small gtpase]] | ||
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Revision as of 14:52, 21 February 2008
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Crystal structure of Rnd3/RhoE: functional implications
OverviewOverview
The Rnd proteins constitute an exceptional subfamily within the Rho GTPase family. They possess extended chains at both termini and four prominent amino acid deviations causing GTPase deficiency. Herein, we report the crystal structure of the Rnd3/RhoE G-domain (amino acids 19-200) at 2.0 A resolution. This is the first GTP-structure of a Rho family member which reveals a similar fold but striking differences from RhoA concerning (i) GTPase center, (ii) charge distribution at several surface areas, (iii) C3-transferase binding site and (iv) interacting interfaces towards RhoA regulators and effectors.
About this StructureAbout this Structure
1M7B is a Single protein structure of sequence from Homo sapiens with and as ligands. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of Rnd3/RhoE: functional implications., Fiegen D, Blumenstein L, Stege P, Vetter IR, Ahmadian MR, FEBS Lett. 2002 Aug 14;525(1-3):100-4. PMID:12163169
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