1m2z: Difference between revisions

[[Image:1m2z.gif|left|200px]]<br /><applet load="1m2z" size="350" color="white" frame="true" align="right" spinBox="true"  

Transcriptional regulation by the glucocorticoid receptor (GR) is mediated by hormone binding, receptor dimerization, and coactivator recruitment. Here, we report the crystal structure of the human GR ligand binding domain (LBD) bound to dexamethasone and a coactivator motif derived from the transcriptional intermediary factor 2. Despite structural similarity to other steroid receptors, the GR LBD adopts a surprising dimer configuration involving formation of an intermolecular beta sheet. Functional studies demonstrate that the novel dimer interface is important for GR-mediated activation. The structure also reveals an additional charge clamp that determines the binding selectivity of a coactivator and a distinct ligand binding pocket that explains its selectivity for endogenous steroid hormones. These results establish a framework for understanding the roles of protein-hormone and protein-protein interactions in GR signaling pathways.

1M2Z is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=BOG:'>BOG</scene> and <scene name='pdbligand=DEX:'>DEX</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M2Z OCA].  

[[Category: Apolito, C J.]]

[[Category: Bledsoe, R B.]]

[[Category: Consler, T G.]]

[[Category: Delves, C J.]]

[[Category: Lambert, M H.]]

[[Category: Mckee, D D.]]

[[Category: Montana, V G.]]

[[Category: Moore, J T.]]

[[Category: Parks, D J.]]

[[Category: Pearce, K H.]]

[[Category: Stanley, T B.]]

[[Category: Stewart, E L.]]

[[Category: Willson, T M.]]

[[Category: Xu, H E.]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:50:58 2008''