1qnt: Difference between revisions
New page: left|200px<br /> <applet load="1qnt" size="450" color="white" frame="true" align="right" spinBox="true" caption="1qnt, resolution 1.90Å" /> '''X-RAY STRUCTURE OF ... |
No edit summary |
||
| Line 8: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
1QNT is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.63 2.1.1.63]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1QNT OCA]]. | 1QNT is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Active as [[http://en.wikipedia.org/wiki/Methylated-DNA--[protein]-cysteine_S-methyltransferase Methylated-DNA--[protein]-cysteine S-methyltransferase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.63 2.1.1.63]]. Structure known Active Site: ACC. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1QNT OCA]]. | ||
==Reference== | ==Reference== | ||
Crystal structure of the human O(6)-alkylguanine-DNA alkyltransferase., Wibley JE, Pegg AE, Moody PC, Nucleic Acids Res. 2000 Jan 15;28(2):393-401. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10606635 10606635] | Crystal structure of the human O(6)-alkylguanine-DNA alkyltransferase., Wibley JE, Pegg AE, Moody PC, Nucleic Acids Res. 2000 Jan 15;28(2):393-401. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10606635 10606635] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Methylated-DNA--[protein]-cysteine S-methyltransferase]] | |||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Moody, P.C.E.]] | [[Category: Moody, P.C.E.]] | ||
| Line 20: | Line 21: | ||
[[Category: methyltransferase]] | [[Category: methyltransferase]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 14:34:33 2007'' | ||
Revision as of 15:29, 30 October 2007
|
X-RAY STRUCTURE OF HUMAN O6ALKYLGUANINE-DNA ALKYLTRANSFERASE
OverviewOverview
The mutagenic and carcinogenic effects of simple alkylating agents are, mainly due to O(6)-alkylation of guanine in DNA. This lesion results in, transition mutations. In both prokaryotic and eukaryotic cells, repair is, effected by direct reversal of the damage by a suicide protein, O(6)-alkylguanine-DNA alkyltransferase. The alkyltransferase removes the, alkyl group to one of its own cysteine residues. However, this mechanism, for preserving genomic integrity limits the effectiveness of certain, alkylating anticancer agents. A high level of the alkyltransferase in many, tumour cells renders them resistant to such drugs. Here we report the, X-ray structure of the human alkyltransferase solved using the technique, of multiple wavelength anomalous dispersion. This structure explains the, ... [(full description)]
About this StructureAbout this Structure
1QNT is a [Single protein] structure of sequence from [Homo sapiens]. Active as [[protein-cysteine_S-methyltransferase Methylated-DNA--[protein]-cysteine S-methyltransferase]], with EC number [2.1.1.63]. Structure known Active Site: ACC. Full crystallographic information is available from [OCA].
ReferenceReference
Crystal structure of the human O(6)-alkylguanine-DNA alkyltransferase., Wibley JE, Pegg AE, Moody PC, Nucleic Acids Res. 2000 Jan 15;28(2):393-401. PMID:10606635 [[Category: Methylated-DNA--[protein]-cysteine S-methyltransferase]]
Page seeded by OCA on Tue Oct 30 14:34:33 2007