1kxg: Difference between revisions
New page: left|200px<br /> <applet load="1kxg" size="450" color="white" frame="true" align="right" spinBox="true" caption="1kxg, resolution 2.00Å" /> '''The 2.0 Ang Resolut... |
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'''The 2.0 Ang Resolution Structure of BLyS, B Lymphocyte Stimulator.'''<br /> | '''The 2.0 Ang Resolution Structure of BLyS, B Lymphocyte Stimulator.'''<br /> | ||
==Overview== | ==Overview== | ||
B lymphocyte stimulator (BLyS), a member of the tumor necrosis factor | B lymphocyte stimulator (BLyS), a member of the tumor necrosis factor (TNF) superfamily, is a cytokine that induces B-cell proliferation and immunoglobulin secretion. We have determined the three-dimensional structure of BLyS to 2.0 A resolution and identified receptor recognition segments using limited proteolysis coupled with mass spectrometry. Similar to other structurally determined TNF-like ligands, the BLyS monomer is a beta-sandwich and oligomerizes to form a homotrimer. The receptor-binding region in BLyS is a deeper, more pronounced groove than in other cytokines. The conserved elements on the 'floor' of this groove allow for cytokine recognition of several structurally related receptors, whereas variations on the 'walls' and outer rims of the groove confer receptor specificity. | ||
==About this Structure== | ==About this Structure== | ||
1KXG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with MG, CIT and DIO as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | 1KXG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene>, <scene name='pdbligand=CIT:'>CIT</scene> and <scene name='pdbligand=DIO:'>DIO</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KXG OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Gentz, R.]] | [[Category: Gentz, R.]] | ||
[[Category: Li, Y.]] | [[Category: Li, Y.]] | ||
[[Category: Morris, T | [[Category: Morris, T S.]] | ||
[[Category: Oren, D | [[Category: Oren, D A.]] | ||
[[Category: Volovik, Y.]] | [[Category: Volovik, Y.]] | ||
[[Category: CIT]] | [[Category: CIT]] | ||
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[[Category: ztnf4]] | [[Category: ztnf4]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:39:02 2008'' | ||
Revision as of 14:39, 21 February 2008
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The 2.0 Ang Resolution Structure of BLyS, B Lymphocyte Stimulator.
OverviewOverview
B lymphocyte stimulator (BLyS), a member of the tumor necrosis factor (TNF) superfamily, is a cytokine that induces B-cell proliferation and immunoglobulin secretion. We have determined the three-dimensional structure of BLyS to 2.0 A resolution and identified receptor recognition segments using limited proteolysis coupled with mass spectrometry. Similar to other structurally determined TNF-like ligands, the BLyS monomer is a beta-sandwich and oligomerizes to form a homotrimer. The receptor-binding region in BLyS is a deeper, more pronounced groove than in other cytokines. The conserved elements on the 'floor' of this groove allow for cytokine recognition of several structurally related receptors, whereas variations on the 'walls' and outer rims of the groove confer receptor specificity.
About this StructureAbout this Structure
1KXG is a Single protein structure of sequence from Homo sapiens with , and as ligands. Full crystallographic information is available from OCA.
ReferenceReference
Structural basis of BLyS receptor recognition., Oren DA, Li Y, Volovik Y, Morris TS, Dharia C, Das K, Galperina O, Gentz R, Arnold E, Nat Struct Biol. 2002 Apr;9(4):288-92. PMID:11862220
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